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Effect of Zinc Supplementation on Glycemic Biomarkers: An Umbrella of Interventional Meta-Analyses Publisher



Daneshvar M1 ; Ghaheri M2 ; Safarzadeh D3 ; Karimi F4 ; Adibhajbagheri P5 ; Ahmadzade M6 ; Haedi A7
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Authors Affiliations
  1. 1. Tehran University of Medical Science, Tehran, Iran
  2. 2. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Vocational School of Health Service, Near East University, Nicosia, Cyprus
  4. 4. Department of Nutrition, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Cardiology, Chamran Cardiovascular Research Education Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Urology, Shahid Labbafinejad Medical Center, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Diabetology and Metabolic Syndrome Published:2024


Abstract

Background: Several studies have evaluated the effects of zinc supplementation on glycemic biomarkers in humans and have demonstrated varying results. We systematically evaluated the literature and performed an umbrella meta-analysis of the effects of zinc supplementation on type 2 diabetes biomarkers. Methods: A comprehensive literature search was conducted in the following databases; PubMed, Embase, Embase, Cochrane Library, Scopus, and Web of Science for studies published up to March 10, 2024. Results: Zinc supplementation was effective in reducing serum FBS (WMD: − 13.58, 95% CI: − 17.38, − 9.77; p < 0.001; SMD: − 0.52, 95% CI − 0.79, − 0.25; p = < 0.001), insulin (SMD: − 0.67, 95% CI − 0.96, − 0.38; p < 0.001), HOMA-IR levels (WMD − 0.52, 95% CI − 0.66, − 0.38; p < 0.001; SMD: − 0.78, 95% CI − 1.02, − 0.42; p < 0.001), and HbA1c (WMD: − 0.35, 95% CI − 0.43, − 0.27; p < 0.001). Conclusion: Zinc supplementation significantly reduced FBS, HOMA-IR, insulin and HbA1c. These findings suggest that zinc is potentially an effective complementary intervention to improve type 2 diabetes biomarkers. © The Author(s) 2024.
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