The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review

The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review Publisher Pubmed

Dadras O¹ ; Afsahi AM² ; Pashaei Z³ ; Mojdeganlou H⁴ ; Karimi A⁵ ; Habibi P³ ; Barzegary A⁶ ; Fakhfouri A⁶ ; Mirzapour P³ ; Janfaza N⁷ ; Dehghani S⁵ ; Afroughi F^{6, 8} ; Dashti M⁹ ; Khodaei S³ Show All Authors

Dadras O¹
Afsahi AM²
Pashaei Z³
Mojdeganlou H⁴
Karimi A⁵
Habibi P³
Barzegary A⁶
Fakhfouri A⁶
Mirzapour P³
Janfaza N⁷
Dehghani S⁵
Afroughi F^{6, 8}
Dashti M⁹
Khodaei S³
Mehraeen E¹⁰
Voltarelli F¹¹
Sabatier JM¹²
Seyedalinaghi S³

Show Affiliations

1. The Excellent Center for Dengue and Community Public Health (EC for DACH), School of Public Health, Walailak University, Nakhon Si Thammarat, Thailand
2. Department of Radiology, School of Medicine, University of California, San Diego (UCSD), La Jolla, CA, United States
3. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran
5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. School of Medicine, Islamic Azad University, Tehran, Iran
7. Internal Medicine Department, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
9. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
10. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
11. Graduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiaba, Brazil
12. Universite Aix-Marseille, Institut deNeuro-physiopathologie (INP), UMR 7051, Faculte de Pharmacie, Marseille, France

Source: Immunity# Inflammation and Disease Published:2022

Abstract

Introduction: Patients with COVID-19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID-19 is still unknown. Therefore, this study aimed to systematically review the association between SARS-CoV-2 viral load and COVID-19 severity. Methods: The relevant studies using the keywords of “COVID-19” and “viral load” were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. A two-step title/abstract screening process was carried out and the eligible studies were included in the study. Results: Thirty-four studies were included from the initial 1015 records. The vast majority of studies have utilized real-time reverse transcription-polymerase chain reaction of the nasopharyngeal/respiratory swabs to report viral load. Viral loads were commonly reported either as cycle threshold (Ct) or log10 RNA copies/ml. Conclusion: The results were inconclusive about the relationship between COVID-19 severity and viral load, as a similar number of studies either approved or opposed this hypothesis. However, the studies denote the direct relationship between older age and higher SARS-CoV-2 viral load, which is a known risk factor for COVID-19 mortality. The higher viral load in older patients may serve as a mechanism for any possible relationships between COVID-19 viral load and disease severity. There was a positive correlation between SARS-CoV-2 viral load and its transmissibility. Nonetheless, further studies are recommended to precisely characterize this matter. © 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Dadras O, et al.. "The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review." Immunity# Inflammation and Disease, vol. 10, no. 3, 2022, pp. -.
APA	Dadras O, Afsahi AM, Pashaei Z, Mojdeganlou H, Karimi A, Habibi P, Barzegary A, Fakhfouri A, Mirzapour P, Janfaza N, Dehghani S, Afroughi F, Dashti M, Khodaei S, Mehraeen E, Voltarelli F, Sabatier JM, Seyedalinaghi S (2022). The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review. Immunity# Inflammation and Disease, 10(3), -.
Chicago	Dadras O, Afsahi AM, Pashaei Z, Mojdeganlou H, Karimi A, Habibi P, Barzegary A, et al.. "The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review." Immunity# Inflammation and Disease 10, no. 3 (2022): -.
Harvard	Dadras O et al. (2022) 'The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review', Immunity# Inflammation and Disease, 10(3), pp. -.
Vancouver	Dadras O, Afsahi AM, Pashaei Z, Mojdeganlou H, Karimi A, Habibi P, et al.. The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review. Immunity# Inflammation and Disease. 2022;10(3):-.
BibTex	@article{ author = {Dadras O and Afsahi AM and Pashaei Z and Mojdeganlou H and Karimi A and Habibi P and Barzegary A and Fakhfouri A and Mirzapour P and Janfaza N and Dehghani S and Afroughi F and Dashti M and Khodaei S and Mehraeen E and Voltarelli F and Sabatier JM and Seyedalinaghi S}, title = {The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review}, journal = {Immunity# Inflammation and Disease}, volume = {10}, number = {3}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Dadras O AU - Afsahi AM AU - Pashaei Z AU - Mojdeganlou H AU - Karimi A AU - Habibi P AU - Barzegary A AU - Fakhfouri A AU - Mirzapour P AU - Janfaza N AU - Dehghani S AU - Afroughi F AU - Dashti M AU - Khodaei S AU - Mehraeen E AU - Voltarelli F AU - Sabatier JM AU - Seyedalinaghi S TI - The Relationship Between Covid-19 Viral Load and Disease Severity: A Systematic Review JO - Immunity# Inflammation and Disease VL - 10 IS - 3 SP - EP - PY - 2022 ER -

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