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Vaccines for Covid-19: A Systematic Review of Feasibility and Effectiveness Publisher



Mehraeen E1 ; Dadras O2 ; Afsahi AM3 ; Karimi A4 ; Pour MM1 ; Mirzapour P1 ; Barzegary A5 ; Behnezhad F6 ; Habibi P7 ; Salehi MA7 ; Vahedi F4 ; Heydari M1 ; Kianzad S8 ; Moradmandbadie B9 Show All Authors
Authors
  1. Mehraeen E1
  2. Dadras O2
  3. Afsahi AM3
  4. Karimi A4
  5. Pour MM1
  6. Mirzapour P1
  7. Barzegary A5
  8. Behnezhad F6
  9. Habibi P7
  10. Salehi MA7
  11. Vahedi F4
  12. Heydari M1
  13. Kianzad S8
  14. Moradmandbadie B9
  15. Javaherian M10
  16. Alinaghi SAS7
  17. Sabatier JM11
Show Affiliations
Authors Affiliations
  1. 1. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  2. 2. The Excellent Center for Dengue and Community Public Helath (EC for DACH), School of Public Health, Walailak University, Nakhon Si Thammarat, Thailand
  3. 3. Department of Radiology, School of Medicine, University of California, San Diego [UCSD], CA, United States
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Islamic Azad University, Tehran, Iran
  6. 6. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. School of Medicine, Iran University of Medical Sciences, Tehran, 7134845794, Iran
  9. 9. Black Dog Institute, University of New South Wales, Sydney, Australia
  10. 10. Department of Physiotherapy, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Universite Aix-Marseille, Institut deNeuro-physiopathologie [INP], UMR 7051, Faculte de Pharmacie, 27 Bd Jean Moulin, Cedex, Marseille, 13385, France

Source: Infectious Disorders - Drug Targets Published:2022


Abstract

; Introduction: Many potential vaccines for COVID-19 are being studied and developed. Several studies have reported on the safety and efficacy of these vaccines. This systematic review aimed to report on the current evidence concerning the feasibility and effectiveness of vaccines for COVID-19. Methods: A systematic search was carried out utilizing the keywords in the online databases, including Scopus, Web of Science, PubMed, Embase, and Cochrane. We included both human and non-human studies because of the vaccine novelty, limiting our ability to include sufficient human studies. Results: This review showed several SARS-CoV-2 vaccines to be currently under development using different platforms, including eight vaccines that are adenovirus-based vectors, six vaccines that are RNA-based formulations, one vaccine being DNA-based formulation, and other vaccines using other platforms, including lipid nanoparticles. Although the safety and efficacy profiles of these vaccines are still under debate, some countries have allowed for emergency use of some vaccines in at-risk populations, such as healthcare workers and the elderly. Conclusion: It is crucial to gather as much clinically relevant evidence as possible regarding the immunogenicity, efficacy, and safety profiles of available vaccines and adhere wisely to CDC protocols and guidelines for vaccine production. © 2022 Bentham Science Publishers.
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