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Covid-19-Related Mortality in Kidney Transplant and Dialysis Patients: Results of the Eracoda Collaboration Publisher Pubmed



Hilbrands LB1 ; Duivenvoorden R1 ; Vart P2, 3, 4 ; Franssen CFM4 ; Hemmelder MH5 ; Jager KJ6 ; Kieneker LM4 ; Noordzij M4 ; Pena MJ7 ; De Vries H4 ; Arroyo D8 ; Covic A9, 10 ; Crespo M11 ; Goffin E12 Show All Authors
Authors
  1. Hilbrands LB1
  2. Duivenvoorden R1
  3. Vart P2, 3, 4
  4. Franssen CFM4
  5. Hemmelder MH5
  6. Jager KJ6
  7. Kieneker LM4
  8. Noordzij M4
  9. Pena MJ7
  10. De Vries H4
  11. Arroyo D8
  12. Covic A9, 10
  13. Crespo M11
  14. Goffin E12
  15. Islam M13
  16. Massy ZA14, 15
  17. Montero N16
  18. Oliveira JP17
  19. Munoz AR18
  20. Sanchez JE19
  21. Sridharan S20
  22. Winzeler R21
  23. Gansevoort RT4
  24. Van Der Net JB22
  25. Essig M23
  26. Du Bufvereijken PWG24
  27. Van Ginneken B24
  28. Maas N24
  29. Vogt L25
  30. Van Jaarsveld BC25
  31. Bemelman FJ25
  32. Klingenbergsalahova F25
  33. Heenanvos F25
  34. Vervloet MG25
  35. Nurmohamed A25
  36. Abramowicz D26
  37. Verhofstede S26
  38. Maoujoud O27
  39. Fialova J28
  40. Melilli E29
  41. Fava A29
  42. Cruzado JM29
  43. Lips J30
  44. Hengst M31
  45. Gellert R32
  46. Rydzewski A33
  47. Alferes DG34
  48. Rychlik I35
  49. Zakharova EV36
  50. Ambuehl PM37
  51. Lepeytre F38
  52. Rabate C38
  53. Rostoker G38
  54. Marques S39
  55. Azasevac T40
  56. Katicic D41
  57. Ten Dam M42
  58. Kruger T43
  59. Logtenberg SJJ44
  60. Fricke L45
  61. Van Zanen AL46
  62. Slebe JJP47
  63. Kemlin D48
  64. Van De Wetering J49
  65. Eiselt J50
  66. Kielberger L50
  67. Elwakil HS51
  68. Elhafeez SA52
  69. Canal C53
  70. Facundo C53
  71. Ramos AM53
  72. Debskaslizien A54
  73. Veldhuizen NMH55
  74. Panagoutsos S56
  75. Matceac I9, 10
  76. Nistor I9, 10
  77. Cordos M9, 10
  78. Groeneveld JHM57
  79. Van Buren M58
  80. Diekmann F59
  81. Ferreira AC60
  82. Ariascabrales C62
  83. Llinasmallol L62
  84. Buxeda A62
  85. Tarrega CB62
  86. Redondopachon D62
  87. Jimenez MDA62
  88. Hofstra JM63
  89. Franco A64
  90. Rodriguezferrero ML65
  91. Manzanos SB66
  92. De Arriba G67
  93. Barrios RHS68
  94. Bartelet K69
  95. Demir E70
  96. Hollander DAMJ71
  97. Kerckhoffs A71
  98. Buttner S72
  99. De Vries APJ73
  100. Meziyerh S73
  101. Van Der Helm D73
  102. Reinders M73
  103. Bouwsma H73
  104. Petruliene K74
  105. Maloney S75
  106. Verberk I76
  107. Di Luca M77
  108. Tuglular SZ78
  109. Beerenhout C79
  110. Luik PT80
  111. Kerschbaum J81
  112. Tiefenthaler M81
  113. Watschinger B82
  114. Adema AY83
  115. Stepanov VA84
  116. Zulkarnaev AB84
  117. Turkmen K85
  118. Decenzio B86
  119. Fliedner A87
  120. Miyasato H88
  121. Asberg A89
  122. Mjoen G89
  123. Pini S90
  124. De Biase C91
  125. Van De Logt AE91
  126. Maas R91
  127. Lebedeva O92
  128. Lopez V93
  129. Reichert LJM94
  130. Verhave J94
  131. Titov D95
  132. Parshina EV96
  133. Van Gilsverrij LEA97
  134. De Bruin CJR98
  135. Harty JC99
  136. Meurs M100
  137. Myslak M101
  138. Battaglia Y102
  139. Lentini P103
  140. Den Deurwaarder E104
  141. Rahimzadeh H105
  142. Schouten M106
  143. Cabezasreina CJ107
  144. Diazmareque A108
  145. Coca A109
  146. Meijers BKI110
  147. Naesens M110
  148. Kuypers D110
  149. Desschans B110
  150. Tonnerlier A111
  151. Wissing KM111
  152. Dedinska I112
  153. Pessolano G113
  154. Van Der Sande FM114
  155. Christiaans MHL114
  156. Gandolfini I115
  157. Maggiore U115
  158. Kanaan N116
  159. Labriola L116
  160. Devresse A116
  161. Malik S117
  162. Berger SP118
  163. Meijer E118
  164. Sanders JSF118
  165. Ponikvar JB119
  166. Abrahams AC120
  167. Molenaar FM120
  168. Van Zuilen AD120
  169. Meijvis SCA120
  170. Dolmans H120
  171. Zanoli L121
  172. Marcantoni C121
  173. Esposito P122
  174. Krzesinski JM123
  175. Barahira JD123
  176. Gallieni M124
  177. Sabiu G124
  178. Martinmoreno PL125
  179. Guglielmetti G126
  180. Guzzo G127
  181. Luik AJ128
  182. Van Kuijk WHM128
  183. Stikkelbroeck LWH128
  184. Hermans MMH128
  185. Rimsevicius L129
  186. Righetti M130
  187. Heitinkter Braak N131
Show Affiliations
Authors Affiliations
  1. 1. Department of Nephrology, Radboud University Medical Center, Radboud University, Nijmegen, Netherlands
  2. 2. Department of Health Evidence, Radboud University Medical Center, Radboud University, Nijmegen, Netherlands
  3. 3. Department of Cardiology, Radboud University Medical Center, Radboud University, Nijmegen, Netherlands
  4. 4. Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
  5. 5. Dutch Renal Registry, Nefrovisie Foundation, Utrecht, Netherlands
  6. 6. ERA-EDTA Registry, Department of Medical Informatics, Amsterdam University Medical Center, Amsterdam Public Health Research Institute, Amsterdam, Netherlands
  7. 7. Department of Clinical Pharmacy & Pharmacology, University Medical Center Groningen, Groningen, Netherlands
  8. 8. Department of Nephrology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
  9. 9. Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  10. 10. Dr Ci Parhon Hospital, Iasi, Romania
  11. 11. Department of Nephrology, Hospital del Mar, Barcelona, Spain
  12. 12. Cliniques Universitaires Saint-Luc, Universite Catholique de Louvain, Brussels, Belgium
  13. 13. Department of Nephrology, Zonguldak Ataturk State Hospital, Zonguldak, Turkey
  14. 14. Division of Nephrology, Ambroise Pare University Hospital, APHP (Assistance Publique-Hopitaux de Paris), UVSQ (University Versailles-Saint-Quentin-en-Yvelines) - Paris Saclay, Boulogne Billancourt, Paris, France
  15. 15. Institut National de la Sante et de la Recherche Medicale (INSERM), Villejuif, France
  16. 16. Department of Nephrology, Bellvitge University Hospital, Hospitalet de Llobregat, Barcelona, Spain
  17. 17. Centrodial, Sao Joao da Madeira, Portugal
  18. 18. Renal Transplant Unit, Toledo University Hospital, Toledo, Spain
  19. 19. Department of Nephrology, Hospital Universitario de Cabuenes, Asturias, Spain
  20. 20. Department of Renal Unit, Lister Hospital, Stevenage, United Kingdom
  21. 21. Institute of Nephrology, City Hospital Waid and Triemli, Zurich, Switzerland
  22. 22. Albert Schweitzer Hospital, Dordrecht, Netherlands
  23. 23. Ambroise Pare Hospital, APHP Paris-Saclay University, Boulogne Billancourt, France
  24. 24. Amphia Hospital, Breda, Netherlands
  25. 25. Amsterdam UMC, Amsterdam, Netherlands
  26. 26. Antwerp University Hospital, Antwerp, Belgium
  27. 27. Avicennes Military Hospital, Faculty of Medicine, Cadi Ayyad University, Marrakech, Morocco
  28. 28. B. Braun Avitum, Litomerice, Czech Republic
  29. 29. Bellvitge University Hospital, Hospitalet de Llobregat, Barcelona, Spain
  30. 30. Bernhoven Hospital, Uden, Netherlands
  31. 31. Catharina Hospital, Eindhoven, Netherlands
  32. 32. Centre of Postgraduate Medical Education, Poland
  33. 33. Central Clinical Hospital of the Ministry of Interior, Warsaw, Poland
  34. 34. Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal
  35. 35. Charles University, Prague, Czech Republic
  36. 36. City Hospital n.a. S.P. Botkin, Moscow, Russian Federation
  37. 37. City Hospital Waid, Zurich, Switzerland
  38. 38. Claude Galien Hospital Ramsay Sante, Quincy-sous-Senart, France
  39. 39. Clinica de Hemodialise de Felgueiras, Felgueiras, Portugal
  40. 40. Clinical Centre of Vojvodina, Novi Sad, Serbia
  41. 41. Croatian Society of Nephrology, Dialysis and Transplantation, Croatia
  42. 42. CWZ Nijmegen, Nijmegen, Netherlands
  43. 43. DaVita Geilenkirchen, Geilenkirchen, Germany
  44. 44. Dianet Dialysis Center, Utrecht, Netherlands
  45. 45. Dialysis Center Bochum, Bochum, Germany
  46. 46. Deventer Ziekenhuis, Deventer, Netherlands
  47. 47. Elyse Klinieken voor Nierzorg, Kerkrade, Netherlands
  48. 48. Erasme Hospital, Brussels, Belgium
  49. 49. Erasmus Medical Center, Rotterdam, Netherlands
  50. 50. Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
  51. 51. Faculty of Medicine-Alexandria University, Alexandria, Egypt
  52. 52. Epidemiology Department, High Institute of Public Health, Alexandria University, Egypt
  53. 53. Fundacion Jimenez Diaz, Madrid, Spain
  54. 54. Gdansk Medical University, Gdansk, Poland
  55. 55. Gelre Hospital, Apeldoorn, Netherlands
  56. 56. General University Hospital of Alexandroupolis, Alexandroupolis, Greece
  57. 57. Haaglanden Medisch Centrum, the Hague, Netherlands
  58. 58. Haga Hospital, the Hague, Netherlands
  59. 59. Hospital Clinic de Barcelona, Barcelona, Spain
  60. 60. Hospital Curry Cabral, Central Lisbon University Hospital Center, Lisbon, Portugal
  61. 61. HC-UFMG, CMN Contagem-MG, Unimed-BH, Brazil
  62. 62. Hospital del Mar, Barcelona, Spain
  63. 63. Hospital Gelderse Vallei, Ede, Netherlands
  64. 64. Hospital General of Alicante, Alicante, Spain
  65. 65. Hospital General Universitario Gregorio Maranon, Madrid, Spain
  66. 66. Hospital Obispo Polanco, Salud Aragon, Spain
  67. 67. Hospital Universitario de Guadalajara, Guadalajara, Spain
  68. 68. Hospital Universitario Ramon y Cajal, Madrid, Spain
  69. 69. Isala, Zwolle, Netherlands
  70. 70. Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
  71. 71. Jeroen Bosch Ziekenhuis, Den Bosch, Netherlands
  72. 72. Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany
  73. 73. Leiden University Medical Center, Leiden, Netherlands
  74. 74. Lithuanian University of Health Sciences, Lithuania
  75. 75. Luzerner Kantonsspital, Luzern, Switzerland
  76. 76. Maasstad Ziekenhuis, Rotterdam, Netherlands
  77. 77. Marche Nord Hospital, Pesaro, Italy
  78. 78. Marmara University School of Medicine, Istanbul, Turkey
  79. 79. Maxima Medisch Centrum, Veldhoven, Netherlands
  80. 80. Meander Medisch Centrum, Amersfoort, Netherlands
  81. 81. Medical University Innsbruck, Innsbruck, Austria
  82. 82. Medical University of Vienna, Vienna, Austria
  83. 83. Medisch Centrum Leeuwarden, Leeuwarden, Netherlands
  84. 84. Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
  85. 85. Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
  86. 86. Nephrology and Dialysis - AUSL Modena, Modena, Italy
  87. 87. Nierenzentrum Reutlingen-Tubingen, Reutlingen, Germany
  88. 88. Okinawa Chubu Hospital, Japan
  89. 89. The Norwegian Renal Registry, Oslo University Hospital - Rikshospitalet, Olso, Norway
  90. 90. Padua University Hospital, Padua, Italy
  91. 91. Radboud University Medical Center, Nijmegen, Netherlands
  92. 92. Regional Clinical Hospital, Yaroslavl, Russian Federation
  93. 93. Regional Hospital of Malaga, Malaga, Spain
  94. 94. Rijnstate Hospital, Arnhem, Netherlands
  95. 95. RUDN University, Russian Federation
  96. 96. Saint-Petersburg State University Hospital, Saint-Petersburg, Russian Federation
  97. 97. Sint Antonius Ziekenhuis, Nieuwegein, Netherlands
  98. 98. Slingeland Ziekenhuis, Doetinchem, Netherlands
  99. 99. Southern Health and Social Care Trust, Newry, United Kingdom
  100. 100. Spaarne Gasthuis, Haarlem, Netherlands
  101. 101. SPWSZ Hospital, Szczecinie, Poland
  102. 102. St. Anna University Hospital, Ferrara, Italy
  103. 103. St. Bassiano Hospital, Bassano del Grappo, Italy
  104. 104. Streekziekenhuis Koningin Beatrix, Winterswijk, Netherlands
  105. 105. Tehran University of Medical Sciences, Theran, Iran
  106. 106. Tergooi, Hilversum, Netherlands
  107. 107. Toledo University Hospital, Toledo, Spain
  108. 108. University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain
  109. 109. University Clinical Hospital of Valladolid, Valladolid, Spain
  110. 110. University Hospital Leuven, Leuven, Belgium
  111. 111. University Hospital Brussels, Brussels, Belgium
  112. 112. University Hospital Martin and Jessenius, Faculty of Medicine, Comenius University, Martin, Slovakia
  113. 113. University Hospital Medical Center Verona, Verona, Italy
  114. 114. University Hospital of Maastricht, Maastricht, Netherlands
  115. 115. University Hospital Parma, Parma, Italy
  116. 116. University Hospital UC Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  117. 117. University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
  118. 118. University Medical Center Groningen, Groningen, Netherlands
  119. 119. University Medical Center Ljubljana, Ljubljana, Slovenia
  120. 120. University Medical Center Utrecht, Utrecht, Netherlands
  121. 121. San Marco Hospital, University of Catania, Catania, Italy
  122. 122. University of Genoa, Genoa, Italy
  123. 123. University of Liege, Liege, Belgium
  124. 124. University of Milan, Milan, Italy
  125. 125. University of Navarra Clinic, Pamplona, Spain
  126. 126. University of Piemonte Orientale, Novara, Italy
  127. 127. Valais Hospital, Sion, Switzerland
  128. 128. VieCuri Medical Centre, Venlo, Netherlands
  129. 129. Vilnius University, Vilnius, Lithuania
  130. 130. Vimercate Hospital, Vimercate, Italy
  131. 131. Zuyderland Medical Center, Geleen and Heerlen, Netherlands

Source: Nephrology Dialysis Transplantation Published:2020


Abstract

Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available on outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed data on kidney transplant and dialysis patients with COVID-19. For this analysis, patients were included who presented between 1 February and 1 May 2020 and had complete information available on the primary outcome parameter, 28-day mortality. Results. Of the 1073 patients enrolled, 305 (28%) were kidney transplant and 768 (72%) dialysis patients with a mean age of 60 6 13 and 67 6 14 years, respectively. The 28-day probability of death was 21.3% [95% confidence interval (95% CI) 14.3–30.2%] in kidney transplant and 25.0% (95% CI 20.2–30.0%) in dialysis patients. Mortality was primarily associated with advanced age in kidney transplant patients, and with age and frailty in dialysis patients. After adjusting for sex, age and frailty, in-hospital mortality did not significantly differ between transplant and dialysis patients [hazard ratio (HR) 0.81, 95% CI 0.59–1.10, P ¼ 0.18]. In the subset of dialysis patients who were a candidate for transplantation (n ¼ 148), 8 patients died within 28 days, as compared with 7 deaths in 23 patients who underwent a kidney transplantation <1 year before presentation (HR adjusted for sex, age and frailty 0.20, 95% CI 0.07–0.56, P < 0.01). Conclusions. The 28-day case-fatality rate is high in patients on kidney replacement therapy with COVID-19 and is primarily driven by the risk factors age and frailty. Furthermore, in the first year after kidney transplantation, patients may be at increased risk of COVID-19-related mortality as compared with dialysis patients on the waiting list for transplantation. This information is important in guiding clinical decision-making, and for informing the public and healthcare authorities on the COVID-19-related mortality risk in kidney transplant and dialysis patients. © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
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