A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population

A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population Publisher Pubmed

Abbasi S¹ ; Rasouli M²

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1. Department of Laboratory Medicine, School of Allied Medical Sciences, Tehran University of Medical Sciences, 17 Farredanesh Alley, Ghoods Street, Enghelab Avenue, Tehran, 14177, Iran
2. Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia

Source: Molecular Medicine Reports Published:2017

Abstract

Fanconi Anemia (FA) is an autosomal recessive syndrome characterized by congenital abnormalities, progressive bone marrow failure and Fanconi anemia complementation group A (FA NCA) is also a potential breast and ovarian cancer susceptibility gene. A novel allele with tandem duplication of 13 base pair sequence in promoter region was identified. To investigate whether the 13 base pair sequence of tandem duplication in promoter region of the FA NCA gene is of high penetrance in patients with breast cancer and to determine if the presence of the duplicated allele was associated with an altered risk of breast cancer, the present study screened DNA in blood samples from 304 breast cancer patients and 295 normal individuals as controls. The duplication allele had a frequency of 35.4 and 21.2% in patients with breast cancer and normal controls, respectively. There was a significant increase in the frequency of the duplication allele in patients with familial breast cancer compared with controls (45.1%, P=0.001). Furthermore, the estimated risk of breast cancer in individuals with a homozygote [odds ratio (OR), 4.093; 95% confidence intervals (CI), 1.957-8.561] or heterozygote duplicated genotype (OR, 3.315; 95% CI, 1.996-5.506) was higher compared with the corresponding normal homozygote genotype. In conclusion, the present study indicated that the higher the frequency of the duplicated allele, the higher the risk of breast cancer. To the best of our knowledge, the present study is the first to report FA NCA gene duplication in patients with breast cancer.

2. Analysis of the Association Between Mdm4 Rs4245739 Single Nucleotide Polymorphism and Breast Cancer Susceptibility, Clinical Laboratory (2016)

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Mohamadreza Neishaboury (1)

Style	Citing Format
MLA	Abbasi S, Rasouli M. "A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population." Molecular Medicine Reports, vol. 15, no. 6, 2017, pp. 3983-3988.
APA	Abbasi S, Rasouli M (2017). A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population. Molecular Medicine Reports, 15(6), 3983-3988.
Chicago	Abbasi S, Rasouli M. "A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population." Molecular Medicine Reports 15, no. 6 (2017): 3983-3988.
Harvard	Abbasi S, Rasouli M (2017) 'A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population', Molecular Medicine Reports, 15(6), pp. 3983-3988.
Vancouver	Abbasi S, Rasouli M. A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population. Molecular Medicine Reports. 2017;15(6):3983-3988.
BibTex	@article{ author = {Abbasi S and Rasouli M}, title = {A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population}, journal = {Molecular Medicine Reports}, volume = {15}, number = {6}, pages = {3983-3988}, year = {2017} }
RIS	TY - JOUR AU - Abbasi S AU - Rasouli M TI - A Rare Fanca Gene Variation As a Breast Cancer Susceptibility Allele in an Iranian Population JO - Molecular Medicine Reports VL - 15 IS - 6 SP - 3983 EP - 3988 PY - 2017 ER -

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