Retinopathy of Prematurity Screening Criteria in Iran: New Screening Guidelines Publisher Pubmed



Roohipoor R¹ ; Karkhaneh R¹ ; Farahani A¹ ; Ebrahimiadib N¹ ; Modjtahedi B² ; Fotouhi A³ ; Yaseri M³ ; Khodabande A¹ ; Zarei M¹ ; Fuladi MI¹ ; Taheri A¹ ; Esfahani MR^{1, 4} ; Loewenstein J² Show Affiliations
Source: Archives of Disease in Childhood: Fetal and Neonatal Edition Published:2016

Abstract

Objective: To test the applicability of existing retinopathy of prematurity (ROP) guidelines on Iranian patients and to develop novel ROP screening criteria in Iran. Methods: Both eyes of 1932 infants born ≤37 weeks of gestation and/or weighting ≤3000 g were included in this prospective cohort study that was conducted across nine neonatal intensive care units and a tertiary eye hospital ROP clinic. The patients were examined for ROP and the need for treatment (type 1 ROP or worse). All the patients were screened 4 weeks after birth or at 31 weeks of postmenstrual age, whichever was later. The patients were followed until retinal vascularisation was completed or the patients reached 50 weeks of gestational age (GA) without prethreshold ROP. A receiver operating characteristic curve was used to determine the best screening criteria for ROP. Screening criteria from other countries were applied to our patient data to determine their ability to appropriately detect ROP. Main outcome measure: Patients with ROP requiring treatment. Results: The mean GA±SD and birth weight (BW)±SD of the screened patients were 32±2.7 weeks and 1713±516 g, respectively. Using criteria of GA≤32 weeks or BW ≤2000 yielded sensitivity and specificity of 100% and 26.7%, respectively, for treatment requiring ROP regardless of clinical comorbidities. Using screening recommendations of American Academy of Pediatrics would miss 25.4% of ROP and 8.4%ROP requiring treatment in our cohort. Conclusions: Other countries screening recommendations would result in a significant amount of missed cases of treatment requiring ROP when applied to Iran. As a result, we have proposed new guidelines for premature babies in Iran. © 2016, BMJ Publishing Group. All rights reserved.