Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Risk Factors for the Time to Development of Retinopathy of Prematurity in Premature Infants in Iran: A Machine Learning Approach Publisher Pubmed



Tapak L1 ; Farahani LN2 ; Taleghani NT3 ; Ebrahimiadib N4 ; Pour E5 ; Farahani AD5 ; Hamidi O6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biostatistics, School of Public Health and Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Clinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, United States
  5. 5. Farabi Eye Hospital, Retina Ward, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Science, Hamedan University of Technology, Hamedan, Iran

Source: BMC Ophthalmology Published:2024


Abstract

Background: Retinopathy of prematurity (ROP), is a preventable leading cause of blindness in infants and is a condition in which the immature retina experiences abnormal blood vessel growth. The development of ROP is multifactorial; nevertheless, the risk factors are controversial. This study aimed to identify risk factors of time to development of ROP in Iran. Methods: This historical cohort study utilized data from the hospital records of all newborns referred to the ROP department of Farabi Hospital (from 2017 to 2021) and the NICU records of infants referred from Mahdieh Hospital to Farabi Hospital. Preterm infants with birth weight (BW) ≤ 2000 g or gestational age (GA) < 34 wk, as well as selected infants with an unstable clinical course, as determined by their pediatricians or neonatologists, with BW > 2000 g or GA ≥ 34 wk. The outcome variable was the time to development of ROP (in weeks). Random survival forest was used to analyze the data. Results: A total of 338 cases, including 676 eyes, were evaluated. The mean GA and BW of the study group were 31.59 ± 2.39 weeks and 1656.72 ± 453.80 g, respectively. According to the criteria of minimal depth and variable importance, the most significant predictors of the time to development of ROP were duration of ventilation, GA, duration of oxygen supplementation, bilirubin levels, duration of antibiotic administration, duration of Total Parenteral Nutrition (TPN), mother age, birth order, number of surfactant administration, and on time screening. The concordance index for predicting survival of the fitted model was 0.878. Conclusion: Our findings indicated that the duration of ventilation, GA, duration of oxygen supplementation, bilirubin levels, duration of antibiotic administration, duration of TPN, mother age, birth order, number of surfactant administrations, and on time screening are potential risk factors of prognosis of ROP. The associations between identified risk factors were mostly nonlinear. Therefore, it is recommended to consider the nature of these relationships in managing treatment and designing early interventions. © The Author(s) 2024.
Related Docs
1. Evaluation of Risk Factors for Retinopathy of Prematurity in Preterm Neonates, Iranian Journal of Neonatology (2019)
2. The Effect of Volume Guarantee Ventilation on the Incidence of Retinopathy of Prematurity, Journal of Comprehensive Pediatrics (2019)
3. Prevalence and Risk Factors of Retinopathy of Prematurity in Iran, Journal of Ophthalmic and Vision Research (2019)
Experts (# of related papers)
View all Related Experts
Nazanin Ebrahimi Adib (1)
Hamed Ghassemi (1)