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Graphene-Based Electrochemical Biosensors for Breast Cancer Detection Publisher Pubmed



Mohammadpourharatbar A1 ; Boraei SBA1 ; Zare Y1 ; Rhee KY2 ; Park SJ3
Authors
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Authors Affiliations
  1. 1. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1715424313, Iran
  2. 2. Department of Mechanical Engineering (BK21 Four), College of Engineering, Kyung Hee University, Yongin, 17104, South Korea
  3. 3. Department of Chemistry, Inha University, Incheon, 22212, South Korea

Source: Biosensors Published:2023


Abstract

Breast cancer (BC) is the most common cancer in women, which is also the second most public cancer worldwide. When detected early, BC can be treated more easily and prevented from spreading beyond the breast. In recent years, various BC biosensor strategies have been studied, including optical, electrical, electrochemical, and mechanical biosensors. In particular, the high sensitivity and short detection time of electrochemical biosensors make them suitable for the recognition of BC biomarkers. Moreover, the sensitivity of the electrochemical biosensor can be increased by incorporating nanomaterials. In this respect, the outstanding mechanical and electrical performances of graphene have led to an increasingly intense study of graphene-based materials for BC electrochemical biosensors. Hence, the present review examines the latest advances in graphene-based electrochemical biosensors for BC biosensing. For each biosensor, the detection limit (LOD), linear range (LR), and diagnosis technique are analyzed. This is followed by a discussion of the prospects and current challenges, along with potential strategies for enhancing the performance of electrochemical biosensors. © 2023 by the authors.
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