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Electrochemical Biosensors Based on Polymer Nanocomposites for Detecting Breast Cancer: Recent Progress and Future Prospects Publisher Pubmed



Mohammadpourharatbar A1 ; Zare Y1 ; Rhee KY2
Authors
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Authors Affiliations
  1. 1. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  2. 2. Department of Mechanical Engineering (BK21 four), College of Engineering, Kyung Hee University, Yongin, South Korea

Source: Advances in Colloid and Interface Science Published:2022


Abstract

In recent years, the second-highest mortality rate of any cancer worldwide has been breast cancer (BC), which is one of the three most common and deadly cancers among women. Detecting BC in its earliest stages facilitates treatment, reduces death risk, and improves survival rates for patients. Biosensors have garnered considerable attention in recent years for the early diagnosis of BC owing to their high sensitivity, simplicity, low cost, and low detection limit compared to other diagnostic technologies. Polymer nanocomposites (PNCs) containing conductive nanoparticles (NPs) have been used as electrochemical biosensors. In this study, we review recent developments in electrochemical biosensors based on PNCs containing metallic NPs and carbon nanomaterials (carbon nanotubes and graphene) for the diagnosis of biomarkers associated with BC. The key performance characteristics of electrochemical biosensors, such as linear detection range, limit of detection (LOD), and response time, along with the numerous BC biomarkers and various NPs for the fabrication of biosensors are discussed. Additionally, future challenges of electrochemical biosensors and hindrances to their use in clinical practice are explored. © 2022 Elsevier B.V.
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