Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Pregnancy Success in Women With Poor Ovarian Response Under Double Ovarian Stimulation or Two Consecutive Conventional Stimulations: A Retrospective Study Publisher



Aleyassin A1 ; Etezadi A2 ; Hazari V3 ; Aghahosseini M1 ; Hosseinimousa S4 ; Najafian A1 ; Sarvi F1 ; Nashtaee MS5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Department of Obstetrics and Gynecology, Rooyesh Infertility Center, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  4. 4. Department of Infertility and IVF, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Reproductive Biology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Obstetrics, Gynecology and Infertility Published:2024


Abstract

Introduction: In some cases, infertile patients have poor ovarian response, so it is necessary to obtain the right number of oocytes with proper stimulation. The number of oocytes obtained is directly related to fertility success. This study was conducted with aim to compare two methods of double stimulation and two regular sequential stimulations and their relationship with pregnancy outcomes. Methods: This prospective cohort study was conducted in Shariati Hospital of Tehran in 2022-2023. A total of 140 women with poor ovarian response based on Bologna criteria who underwent oocyte puncture were selected for in vitro fertilization. Among these, 70 women with double stimulation and 70 women with two consecutive normal stimulations after embryo transfer were compared in terms of clinical pregnancy rate and cumulative live birth rate. T-test or Mann-Whitney test was used to examine quantitative variables and chi-square test was used to examine qualitative variables. Data analysis was done using SPSS statistical software (version 24). P<0.05 was considered significant. Results: The results showed that although the percentage of clinical pregnancy (p=0.28) and live birth (p=0.5) was higher in the group under double stimulation, however, no significant relationship was observed between them. It was also found that the number of MII oocytes and follicles greater than 14 mm and the number of frozen embryos was higher in the group of double stimulation compared to the other group, which was statistically significant (p<0.05). Conclusion: The double stimulation compared to regular sequential stimulation had no superiority in pregnancy outcomes, including chemical and clinical pregnancy. However, it can increase the number of MII eggs, follicles larger than 14 mm and the number of frozen embryos. © 2024, Mashhad University of Medical Sciences. All rights reserved.
Related Docs
1. Investigating Ovulation Induction Outcomes in Patients With Decreased Ovarian Reserve Treated With Double Stimulation During the Follicular and Luteal Phases Compared to the Conventional Antagonist Cycle: A Randomized Clinical Trial, International Journal of Fertility and Sterility (2024)
2. The Knowledge Domain and Emerging Trends in the Infertility Field: A 67-Year Retrospective Study, Health Care for Women International (2024)
3. Sperm Epigenetics and Male Infertility: Unraveling the Molecular Puzzle, Human Genomics (2024)
4. The Effect of Female, Male and Sonographic Factors on the Success Rate of Intrauterine Insemination in Infertility Patients: A Single-Center Retrospective Study, Iranian Journal of Obstetrics, Gynecology and Infertility (2024)
Experts (# of related papers)
View all Related Experts
Razieh Akbari (1)
Zahra Panahi (1)