The Association of the Vitamin D Status With the Persistence of Anti-Hbs Antibody at 20 Years After Primary Vaccination With Recombinant Hepatitis B Vaccine in Infancy Publisher Pubmed



Jafarzadeh A^{1, 2, 3} ; Keshavarz J^{1, 2} ; Bagherijamebozorgi M² ; Nemati M³ ; Frootan R⁴ ; Shokri F⁵ Show Affiliations
Source: Clinics and Research in Hepatology and Gastroenterology Published:2017

Abstract

Background and objective Vitamin D has potent immunoregulatory effects due to the expression of its receptor on the majority of immune cells. The aim was to evaluate the association of the vitamin D status with the persistence of anti-HBs antibody and immune response to booster immunization at 20 years after primary vaccination with hepatitis B (HB) vaccine. Methods Blood samples were collected from 300 adults 20 years after completion of the primary HB vaccination in infancy. The serum levels of vitamin D and anti-HBs antibody were measured by ELISA. A single booster dose of a recombinant HB vaccine was administered to a total of 138 subjects, whose anti-HBs titer was < 10 IU/L. The sera of revaccinated subjects were re-tested for anti-HBs antibody, 4 weeks after booster vaccination. Results At 20 years after primary vaccination, the mean vitamin D concentrations were significantly higher in seroprotective subjects as compared to non-seroprotective individuals (P < 0.01). The levels of anti-HBs were significantly increased with advanced concentrations of vitamin D (P < 0.01). Overall, 125/138 (90.6%) of the revaccinated subjects showed an anamnestic response to booster vaccination. The concentrations of vitamin D were significantly higher in subjects with an anamnestic response to booster vaccination as compared with subjects without this response (P < 0.01). Conclusion Vitamin D status may influence the persistence of anti-HBs antibody and durability of protection after primary vaccination with a recombinant HB vaccine in infancy. © 2016 Elsevier Masson SAS