Supramolecular Cyclodextrin-Based Metal-Organic Frameworks (Mofs): Advanced Food Applications Publisher Pubmed



Khezerlou A ; Rezvani Ghalhari M ; Alizadeh Sani MA ; Mcclements DJ
Source: Advances in Colloid and Interface Science Published:2025

Abstract

Supramolecular cyclodextrin-based metal-organic frameworks (CD-MOFs) have several potential applications in the food industry, including as packaging materials, sensor components, adsorbents, and food additives. These porous, biocompatible materials combine the host-guest chemistry of cyclodextrins with the tunable structure of MOFs, enabling their properties to be tailored for specific applications within the food industry. In active and smart food packaging, CD-MOFs facilitate controlled release of encapsulated antimicrobial agents and antioxidants, thereby enhancing food quality, safety, and shelf life. Encapsulation of bioactive compounds, such as colors, flavors, nutraceuticals, and preservatives, in CD-MOFs can protect them from chemical degradation, microbial contamination, and volatilization. In food formulation, these supramolecular complexes enable the targeted delivery of functional additives, thereby improving sensory attributes and nutritional profiles. The biodegradable nature of many CD-MOFs aligns with the demand for eco-friendly materials, thereby reducing reliance on synthetic additives. Furthermore, CD-MOFs can be integrated into smart sensors to detect spoilage or contamination, ensuring real-time quality monitoring. Previous research suggests that CD-MOFs may provide innovative solutions to enhance food preservation, nutrition, and sustainability. However, challenges such as scalability, cost, and regulatory hurdles must be addressed to unlock their full potential. Continued research and development, coupled with interdisciplinary collaboration, will be crucial in overcoming these limitations and integrating CD-MOFs into food applications. © 2025 Elsevier B.V., All rights reserved.