High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy

High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy Publisher Pubmed

Robatjazi B¹ ; Hosseini M¹ ; Shaygannejad V² ; Nafissi S³ ; Rezaei A¹ ; Mansourain M⁴ ; Mirmosayyeb O⁵ ; Esmaeil N¹

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan, Iran
3. Department of Neurology, Iranian Center for Neurological Research, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
5. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: NeuroImmunoModulation Published:2018

Abstract

Objectives: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. Methods: Twelve pre-and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. Results: The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (p < 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (p < 0.05). Conclusion: Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis. © 2018 S. Karger AG, Basel. All rights reserved.

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Style	Citing Format
MLA	Robatjazi B, et al.. "High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy." NeuroImmunoModulation, vol. 25, no. 2, 2018, pp. 80-88.
APA	Robatjazi B, Hosseini M, Shaygannejad V, Nafissi S, Rezaei A, Mansourain M, Mirmosayyeb O, Esmaeil N (2018). High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy. NeuroImmunoModulation, 25(2), 80-88.
Chicago	Robatjazi B, Hosseini M, Shaygannejad V, Nafissi S, Rezaei A, Mansourain M, Mirmosayyeb O, Esmaeil N. "High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy." NeuroImmunoModulation 25, no. 2 (2018): 80-88.
Harvard	Robatjazi B et al. (2018) 'High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy', NeuroImmunoModulation, 25(2), pp. 80-88.
Vancouver	Robatjazi B, Hosseini M, Shaygannejad V, Nafissi S, Rezaei A, Mansourain M, et al.. High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy. NeuroImmunoModulation. 2018;25(2):80-88.
BibTex	@article{ author = {Robatjazi B and Hosseini M and Shaygannejad V and Nafissi S and Rezaei A and Mansourain M and Mirmosayyeb O and Esmaeil N}, title = {High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy}, journal = {NeuroImmunoModulation}, volume = {25}, number = {2}, pages = {80-88}, year = {2018} }
RIS	TY - JOUR AU - Robatjazi B AU - Hosseini M AU - Shaygannejad V AU - Nafissi S AU - Rezaei A AU - Mansourain M AU - Mirmosayyeb O AU - Esmaeil N TI - High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy JO - NeuroImmunoModulation VL - 25 IS - 2 SP - 80 EP - 88 PY - 2018 ER -

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