Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis

Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis Publisher Pubmed

Hosseini M¹ ; Robatjazi B¹ ; Shaygannejad V⁴ ; Naffisi S⁵ ; Mirmossayeb O^{3, 4} ; Rezaei A¹ ; Mansourian M² ; Esmaeil N¹

Show Affiliations

1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran
2. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3. Medical Stud Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4. Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
5. Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: NeuroImmunoModulation Published:2018

Abstract

Objective: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most patients have thymic pathology, and thymectomy (TE) can reduce the severity of the disease. Methods: In this study, the frequency of Th17 and Tc17 cells was studied in 12 MG patients (pre-TE and 6 months post-TE) and in 12 healthy controls (HC). Results: The frequency of Tc17 cells in the pre-TE patients was significantly higher than in the HC (p < 0.05), and after TE, these cells had significantly decreased compared to before TE (p < 0.05). The frequency of Th17 cells in pre-TE patients was significantly higher than in the HC (p < 0.05), and after TE, these cells had significantly decreased compared to before TE (p < 0.05). Conclusion: Our findings indicated a possible role of Tc17 and Th17 in MG pathogenesis. © 2018 S. Karger AG, Basel.

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Style	Citing Format
MLA	Hosseini M, et al.. "Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis." NeuroImmunoModulation, vol. 24, no. 4-5, 2018, pp. 264-270.
APA	Hosseini M, Robatjazi B, Shaygannejad V, Naffisi S, Mirmossayeb O, Rezaei A, Mansourian M, Esmaeil N (2018). Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis. NeuroImmunoModulation, 24(4-5), 264-270.
Chicago	Hosseini M, Robatjazi B, Shaygannejad V, Naffisi S, Mirmossayeb O, Rezaei A, Mansourian M, Esmaeil N. "Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis." NeuroImmunoModulation 24, no. 4-5 (2018): 264-270.
Harvard	Hosseini M et al. (2018) 'Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis', NeuroImmunoModulation, 24(4-5), pp. 264-270.
Vancouver	Hosseini M, Robatjazi B, Shaygannejad V, Naffisi S, Mirmossayeb O, Rezaei A, et al.. Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis. NeuroImmunoModulation. 2018;24(4-5):264-270.
BibTex	@article{ author = {Hosseini M and Robatjazi B and Shaygannejad V and Naffisi S and Mirmossayeb O and Rezaei A and Mansourian M and Esmaeil N}, title = {Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis}, journal = {NeuroImmunoModulation}, volume = {24}, number = {4-5}, pages = {264-270}, year = {2018} }
RIS	TY - JOUR AU - Hosseini M AU - Robatjazi B AU - Shaygannejad V AU - Naffisi S AU - Mirmossayeb O AU - Rezaei A AU - Mansourian M AU - Esmaeil N TI - Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis JO - NeuroImmunoModulation VL - 24 IS - 4-5 SP - 264 EP - 270 PY - 2018 ER -

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