Investigating the Relationship Between the Vntr Variant of the Interleukin-1 Receptor Antagonist Gene and Coronary In-Stent Restenosis Publisher Pubmed



Klashami ZN¹ ; Mostafavi A² ; Roudbordeh MG² ; Abbasi A² ; Ebrahimi P³ ; Asadi M⁴ ; Amoli MM¹ Show Affiliations
Source: Molecular Biology Reports Published:2023

Abstract

Objective: This study aimed to examine the association between the interleukin-1 receptor antagonist gene (IL-1RN) and coronary in-stent restenosis (ISR) through the analysis of the VNTR variant based on the previously reported results. Materials and methods: The samples were classified into two clearly defined groups: the case group, which comprised 45 patients diagnosed with in-stent restenosis (ISR+), and the control group, which included 60 patients without ISR (ISR-). Polymerase chain reaction (PCR) was performed to examine the 86-bp VNTR variant of the IL-1RN gene. Results: In the analysis of six identified groups consisting of variant alleles of 86 base pairs of VNTR of the IL-1RN gene statistically significant difference was observed for the presence of IL1RN*2 allele between cases and controls (p = 0.04, OR; 0.045). Conclusion: Individuals with allele 2 of the IL-1Ra gene may be more predisposed to ISR. This could be due to an imbalance between IL-1Ra and IL-1β which is crucial in preventing the initiation or advancement of inflammatory diseases in specific organs. The observed phenomenon can be characterized by increased production of IL-1β and potential reduction of IL-1Ra as a result of functional VNTR variation in IL-RN gene. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.