Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Epigenetic Control of Atherosclerosis Via Dna Methylation: A New Therapeutic Target? Publisher Pubmed



Gorabi AM1 ; Penson PE2 ; Banach M3, 4 ; Motallebnezhad M5, 6, 7 ; Jamialahmadi T9 ; Sahebkar A8, 10, 11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom
  3. 3. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland
  4. 4. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
  5. 5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Halal Research Center of IRI, FDA, Tehran, Iran
  9. 9. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Life Sciences Published:2020


Abstract

Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, including DNA methylation, histone modifications, and microRNAs are involved in the modulation of genes that play distinct roles in several aspects of cell biology and physiology, hence linking environmental stimuli to gene regulation. Recent research has investigated the involvement of DNA methylation in the etiopathogenesis of atherosclerosis, and several studies have documented the role of this mechanism in various aspects of the disease. Regulation of DNA methylation plays a critical role in the integrity of ECs, SMC proliferation and formation of atherosclerotic lesions. In this review, we seek to clarify the role of DNA methylation in the development of atherosclerosis through different mechanisms. © 2020 Elsevier Inc.
Related Docs
View other Related Docs
1. The Role of Mesenchymal Stem Cells in Atherosclerosis: Prospects for Therapy Via the Modulation of Inflammatory Milieu, Journal of Clinical Medicine (2019)
2. Statin Therapy and Lipid Indices in Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Control Trials, Current Pharmaceutical Design (2024)
3. Effects of Statins on the Biological Features of Mesenchymal Stem Cells and Therapeutic Implications, Heart Failure Reviews (2021)
4. Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications, Journal of Clinical Medicine (2019)
5. Antiviral Effects of Statins, Progress in Lipid Research (2020)
6. Effect of Statins on Serum Level of Hs-Crp and Crp in Patients With Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Mediators of Inflammation (2022)
7. Neuroprotective Agents in the Intensive Care Unit, Journal of Pharmacopuncture (2018)
8. Parenteral Systems for Statin Delivery: A Review, Lipids in Health and Disease (2019)
Experts (# of related papers)
View all Related Experts
Mahdi Mahmoudi (4)
Ahmad Reza Jamshidi (3)
Other Related Docs
9. Application of Nanotechnology to Improve the Therapeutic Benefits of Statins, Drug Discovery Today (2019)
10. The Effect of Cryopreservation on Dna Methylation Patterns of the Chromosome 15Q11–Q13 Region in Human Spermatozoa, Cell and Tissue Banking (2020)
11. The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis, Biomolecules (2019)
12. Covid-19 Is an Endothelial Disease: Implications of Nitric Oxide, Advances in Experimental Medicine and Biology (2021)
13. Implications of Micrornas in the Pathogenesis of Atherosclerosis and Prospects for Therapy, Current Drug Targets (2021)
14. The Role of Dna Methylation in Progression of Neurological Disorders and Neurodegenerative Diseases As Well As the Prospect of Using Dna Methylation Inhibitors As Therapeutic Agents for Such Disorders, IBRO Neuroscience Reports (2023)
15. Dna Methylation in Human Diseases, Heliyon (2024)
16. Statin Therapy and C-Reactive Protein in Patients With Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Current Drug Targets (2025)
17. Methylation in Colorectal Cancer, Epigenetics Territory and Cancer (2015)
18. New Insights to the Mechanisms Underlying Atherosclerosis in Rheumatoid Arthritis, International Journal of Rheumatic Diseases (2017)
19. A Review of Gene- and Cell-Based Therapies for Familial Hypercholesterolemia, Pharmacological Research (2019)
20. Effect of Statins on the Plasma/Serum Levels of Inflammatory Markers in Patients With Cardiovascular Disease; a Systematic Review and Meta-Analysis of Randomized Clinical Trials, Inflammopharmacology (2022)
21. Epigenetic Modifications and Epigenetic Based Medication Implementations of Autoimmune Diseases, Biomedicine and Pharmacotherapy (2017)
22. The Effect of the Ovarian Varicose Vein on the Dna Methylation in the Rat’S Oocyte, Iranian Journal of Basic Medical Sciences (2017)
23. Future Challenges and Prospects for the Epigenetics of Autoimmunity, The Epigenetics of Autoimmunity (2018)
24. New Insights Toward the Pathogenesis of Ankylosing Spondylitis; Genetic Variations and Epigenetic Modifications, Modern Rheumatology (2017)
25. Investigating the Relationship Between the Vntr Variant of the Interleukin-1 Receptor Antagonist Gene and Coronary In-Stent Restenosis, Molecular Biology Reports (2023)
26. A Glance at the Therapeutic Potential of Irisin Against Diseases Involving Inflammation, Oxidative Stress, and Apoptosis: An Introductory Review, Pharmacological Research (2018)
27. Effect of Cytomegalovirus Exposure on the Atherosclerotic Events Among Kidney-Transplanted Patients, a Systematic Review and Meta-Analysis, Nephro-Urology Monthly (2018)
28. Epigenetic Modifications and Therapy in Multiple Sclerosis, NeuroMolecular Medicine (2017)
29. Fluorimetric Detection of Methylated Dna of Sept9 Promoter by Silver Nanoclusters at Intrastrand 6C-Loop, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy (2021)
30. Epigenetic Involvement in Etiopathogenesis and Implications in Treatment of Systemic Lupus Erythematous, Inflammation Research (2017)
31. Micrornas As the Actors in the Atherosclerosis Scenario, Journal of Physiology and Biochemistry (2020)
32. Analysis of Helios Gene Expression and Foxp3 Tsdr Methylation in the Newly Diagnosed Rheumatoid Arthritis Patients, Immunological Investigations (2018)
33. Statins: Beneficial Effects in Treatment of Covid-19, Advances in Experimental Medicine and Biology (2023)
34. Regulatory Effects of Statins on Sirt1 and Other Sirtuins in Cardiovascular Diseases, Life (2022)
35. Statins Block Mammalian Target of Rapamycin Pathway: A Possible Novel Therapeutic Strategy for Inflammatory, Malignant and Neurodegenerative Diseases, Inflammopharmacology (2023)
36. Environmental Toxicants, Incidence of Degenerative Diseases, and Therapies From the Epigenetic Point of View, Archives of Toxicology (2017)
37. Dna Methyltransferase Activity Detection Based on Graphene Quantum Dots Using Fluorescence and Fluorescence Anisotropy, Sensors and Actuators# B: Chemical (2017)
38. Non-Invasive Diagnosis of Early-Onset Coronary Artery Disease Based on Cell Type-Specific Gene Expression Analyses, Biomedicine and Pharmacotherapy (2018)
39. Investigating Prevalence and Pattern of Long-Term Cardiovascular Disorders in Sulphur Mustard-Exposed Victims and Determining Proper Biomarkers for Early Defining, Monitoring and Analysis of Patients’ Feedback on Therapy, Basic and Clinical Pharmacology and Toxicology (2017)
40. Circulating Ctdna Methylation Quantification of Two Dna Methyl Transferases in Papillary Thyroid Carcinoma, Journal of Cellular Biochemistry (2019)
41. Effect of Statins on the Blood Lipid Profile in Patients With Different Cardiovascular Diseases: A Systematic Review With Meta-Analysis of Randomized Clinical Trials, Current Medicinal Chemistry (2023)
42. Dnmt1 and Mirnas: Possible Epigenetics Footprints in Electromagnetic Fields Utilization in Oncology, Medical Oncology (2021)