Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis

Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis Publisher Pubmed

Hashemishahraki A¹ ; Heidarieh P² ; Bostanabad SZ³ ; Hashemzadeh M⁴ ; Feizabadi MM⁵ ; Schraufnagel D⁶ ; Mirsaeidi M⁷

Show Affiliations

1. Department of Epidemiology, Pasture Institute of Iran, Tehran, Iran
2. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Alborz, Iran
3. Biology and Microbiology Department, Islamic Azad University, Parand Branch, Tehran, Iran
4. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Division of Pulmonary and Critical Care, University of Illinois at Chicago, Chicago, IL, United States
7. Division of Pulmonary and Critical Care, University of Miami, Miami, FL, United States

Source: Scientific Reports Published:2015

Abstract

The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the β subunit of DNA topoisomerase (gyrB), and 16S rRNA and subunit A of SecA preproteintranslocase (secA1). Antimicrobial susceptibility testing was performed following the Clinical and Laboratory Standards Institute recommendations. Thirty-five N. cyriacigeorgica, 30 N. asteroides, 26 N. farcinica, 12 N. otitidiscaviarum, and 10 N. abscessus cultures were studied. All isolates were susceptible to linezolid. All isolates of N. cyriacigeorgica, N. asteroides, N. abscessus, and N. otitidiscaviarum were susceptible to trimethoprim-sulfamethoxazole, while 8% of N. farcinica isolates were resistant to this drug. All N. otitidiscaviarum isolates were highly resistant to imipenem, but N. cyriacigeorgica, N. asteroides, N. farcinica, and N. abscessus were only moderate resistant. The susceptibility patterns vary with different species of Nocardia. Resistance to trimethoprim-sulfamethoxazole in Iran is low and this drug should be first line therapy, unless drug susceptibility testing shows resistance. Linezolid also covers Nocardia well and could be a second line agent.

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Style	Citing Format
MLA	Hashemishahraki A, et al.. "Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis." Scientific Reports, vol. 5, no. , 2015, pp. -.
APA	Hashemishahraki A, Heidarieh P, Bostanabad SZ, Hashemzadeh M, Feizabadi MM, Schraufnagel D, Mirsaeidi M (2015). Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis. Scientific Reports, 5(), -.
Chicago	Hashemishahraki A, Heidarieh P, Bostanabad SZ, Hashemzadeh M, Feizabadi MM, Schraufnagel D, Mirsaeidi M. "Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis." Scientific Reports 5, no. (2015): -.
Harvard	Hashemishahraki A et al. (2015) 'Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis', Scientific Reports, 5(), pp. -.
Vancouver	Hashemishahraki A, Heidarieh P, Bostanabad SZ, Hashemzadeh M, Feizabadi MM, Schraufnagel D, et al.. Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis. Scientific Reports. 2015;5():-.
BibTex	@article{ author = {Hashemishahraki A and Heidarieh P and Bostanabad SZ and Hashemzadeh M and Feizabadi MM and Schraufnagel D and Mirsaeidi M}, title = {Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis}, journal = {Scientific Reports}, volume = {5}, number = {}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Hashemishahraki A AU - Heidarieh P AU - Bostanabad SZ AU - Hashemzadeh M AU - Feizabadi MM AU - Schraufnagel D AU - Mirsaeidi M TI - Genetic Diversity and Antimicrobial Susceptibility of Nocardia Species Among Patients With Nocardiosis JO - Scientific Reports VL - 5 IS - SP - EP - PY - 2015 ER -

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