Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cancer Stem Cells and Chemoresistance in Glioblastoma Multiform: A Review Article Pubmed



Safari M1 ; Khoshnevisan A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Stem Cells Published:2015


Abstract

Glioblastomamultiforme (GBM) is the most common malignant and aggressive primary tumor of the brain in adults and characterized by a heterogeneous population of cells that are genetically unstable, highly infiltrative, angiogenic, and resistant to chemotherapy. Considerable efforts being devoted to identifying the molecular basis of resistance in GBM and exploring novel therapeutic targets that may improve overall survival.Several independent DNA repair mechanisms that normally safeguard genome integrity can facilitate drug resistance and cancer cell survival by removing chemotherapy-induced adducts. The recent data suggest that the most important mechanism of resistance to alkylating agents is the DNA repair enzyme O6-methylguanine methyltransferase (MGMT). Although, the treatment failure is a result of a number of causes, but currently, it has been demonstrated that a highly tumorigenic subpopulation of cancer cells called glioblastoma stem cells (GSCs) display relative resistance to radiation and chemotherapy. In fact, GBM stem cells express high levels of MGMT and this may account for GBM resistance following chemotherapy. GSCs also contribute to tumor growth through the stimulation of angiogenesis, which has been shown to be a useful therapeutic target in the treatment of recurrent or progressive malignant gliomas. In this review, we summarize the chemoresistance mechanisms of GBMs (to alkylating agents), with a special focus on the role of cancer stem cells. © Nova Science Publishers, Inc.
Related Docs
View other Related Docs
1. Cancer Stem Cells and Chemoresistance in Glioblastoma Multiform: A Review Article, Stem Cells: Mediated Regeneration (2016)
2. Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors, Cellular and Molecular Neurobiology (2018)
3. Non-Coding Rnas and Glioma: Focus on Cancer Stem Cells, Molecular Therapy Oncolytics (2022)
4. Targeting Cancer Stem Cell-Specific Markers And/Or Associated Signaling Pathways for Overcoming Cancer Drug Resistance, Tumor Biology (2016)
5. Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review, International Journal of Stem Cells (2019)
6. Glioblastoma Cancer Stem Cell Biology: Potential Theranostic Targets, Drug Resistance Updates (2019)
7. A Study of Platelet-Derived Growth Factor a and Its Ligand Among Patients With Glioblastoma and Astrocytoma in Imam Khomeini Hospital Complex, Tehran, Journal of Advances in Medical and Biomedical Research (2023)
8. Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells, Scientific Reports (2017)
Experts (# of related papers)
View all Related Experts
Nasim Vousooghi (2)
Amir Hossein Emami (1)
Other Related Docs
9. Cancer Stem Cell-Targeted Chimeric Antigen Receptor (Car)-T Cell Therapy: Challenges and Prospects, Acta Pharmaceutica Sinica B (2021)
10. Dendritic Cell Based Immunotherapy Using Tumor Stem Cells Mediates Potent Antitumor Immune Responses, Cancer Letters (2016)
11. Clinicopathological Significance of Tumor Stem Cell Markers Aldh1 and Cd133 in Colorectal Carcinoma, Iranian Journal of Pathology (2021)
12. Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights Into Its Regulatory Mechanisms, Mini-Reviews in Medicinal Chemistry (2021)
13. Immunopathology and Immunotherapy of Central Nervous System Cancer, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
14. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)
15. Genetic and Cellular Complexity of Brain Tumors, Cancer Genetics and Psychotherapy (2017)
16. Exosomal Noncoding Rnas: Key Players in Glioblastoma Drug Resistance, Molecular and Cellular Biochemistry (2021)
17. Rolipram Potentiates Bevacizumab-Induced Cell Death in Human Glioblastoma Stem-Like Cells, Life Sciences (2017)
18. The Role of Kinase Signaling in Resistance to Bevacizumab Therapy for Glioblastoma Multiforme, Cancer Biotherapy and Radiopharmaceuticals (2019)
19. Cancer Stem Cell’S Potential Clinical Implications, International Journal of Cancer Management (2017)
20. Cellular Conversations in Glioblastoma Progression, Diagnosis and Treatment, Cellular and Molecular Neurobiology (2023)
21. Distinct Gene Expression Patterns of Sox2 and Sox2ot Variants in Different Types of Brain Tumours, Journal of Genetics (2023)
22. Stat3 Targeting by Polyphenols: Novel Therapeutic Strategy for Melanoma, BioFactors (2017)
23. Therapeutic Potentials of Curcumin in the Treatment of Glioblstoma, European Journal of Medicinal Chemistry (2020)
24. The Importance of the Circrna/Wnt Axis in Gliomas: Biological Functions and Clinical Opportunities, Pathology Research and Practice (2024)
25. Local Immunotherapy of Glioblastoma: A Comprehensive Review of the Concept, Journal of Neuroimmunology (2023)
26. Modulation of Cancer Cell Signaling by Long Noncoding Rnas, Journal of Cellular Biochemistry (2019)
27. Targeting Bmi-1 With Plga–Peg Nanoparticle-Containing Ptc209 Modulates the Behavior of Human Glioblastoma Stem Cells and Cancer Cells, Cancer Nanotechnology (2021)