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Non-Coding Rnas Enhance the Apoptosis Efficacy of Therapeutic Agents Used for the Treatment of Glioblastoma Multiform Publisher Pubmed



Ghaemi S1 ; Fekrirad Z1, 2 ; Zamani N1 ; Rahmani R1 ; Arefian E1, 3
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran
  2. 2. Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
  3. 3. Pediatric Cell and Gene Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Drug Targeting Published:2022


Abstract

The treatment of brain tumours remains a challenge despite progress in surgical techniques and radio/chemotherapy. The therapeutic outcomes for glioblastoma multiform (GBM) have not been satisfactory and result in median overall survival (12–18 months). GBM displays both intra- and inter-tumour heterogeneity, causing resistance and eventually tumour recurrence. In this review, we address molecular events responsible for the dysregulation of apoptosis and introduce newly discovered non-coding RNAs (MicroRNAs and Long non-coding RNAs) that regulate tumour growth and enhance therapeutic outcomes in GBM. The combinatory use of MicroRNAs and Long non-coding RNAs with chemotherapeutic compounds, as well as the induction of suicide genes, provide an innovative therapeutic approach for the management of GBM. The understanding of GBM pathogenesis, intrinsic drug resistance mechanism, and targetable oncogenic pathways could lead to establishing novel approaches and techniques to combat GBM. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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