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One-Pot Controllable Synthesis of Carboxylic Group Functionalized Hollow Mesoporous Silica Nanospheres for Efficient Cisplatin Delivery Publisher



Jomeh Farsangi Z1 ; Beitollahi A2 ; Hatton BD3 ; Sarkar S1 ; Jaafari MR4 ; Rezayat M1 ; Amani A1 ; Gheybi F1
Authors
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Authors Affiliations
  1. 1. School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran
  2. 2. School of Metallurgy and Materials Eng., Iran University of Science and Technology, Iran
  3. 3. Department of Materials Science and Eng., University of Toronto, Canada
  4. 4. Department of Pharmaceutical Sciences, Mashhad University of Medical Sciences, Iran

Source: RSC Advances Published:2016


Abstract

Biocompatible hollow porous materials, due to their high void volume and shell porosity, are favorable platforms for efficient drug delivery. In this study, carboxylic group functionalized hollow mesoporous silica nanospheres (HMSNs-COOH) were successfully synthesized in a simple and one-pot co-condensation method using polystyrene nanospheres as a hard template, and carboxyethylsilanetriol as a source of carboxyl groups and reaction catalyzer. The synthesized HMSNs-COOH were studied by characterizing their morphology, nanostructure, specific surface area, particle size distribution and chemical composition using FESEM, HRTEM, SAXRD, N2-sorption, DLS, FTIR and TGA techniques. The large specific surface area measured (973 m2 g-1) for the prepared HMSNs-COOH was found to increase the loading capacity of cisplatin to ∼48%, as an anti-neoplastic agent. Furthermore, release tests performed at three different pH values of 7.4, 6.5 and 5.5 showed a sustained and pH dependent release of the drug from the prepared HMSNs-COOH. The cytotoxicity of the formulated drug was also examined in c26 colon carcinoma cell lines using the MTT assay. We demonstrate that the drug loaded HMSNs-COOH samples have a lower toxicity than the free drug, due to controlled and sustained drug release. © The Royal Society of Chemistry 2016.