Tehran University of Medical Sciences

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Hollow Mesoporous Silica Sphere (Hmss) As a Recyclable Nano-Catalyst in an Efficient One-Pot Multicomponent Synthesis of 2-Amino-3-Cyano-4H-Pyran Derivatives Publisher



Nejatishendi M1 ; Tebyanian H2 ; Zare R3 ; Ayoubichianeh M1 ; Roshani K4 ; Kassaee MZ1 ; Rashidiani J5
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Tarbiat Modares University, P. O. Box 14155-4838, Tehran, Iran
  2. 2. Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Chemistry, Bu-Ali Sina University, Hamadan, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Nanobiotechnology Research Centre, Baqiyatallah University of Medical Science, Tehran, Iran

Source: Biointerface Research in Applied Chemistry Published:2020


Abstract

Mesoporous material has a significant role in medicine, health care, environmental monitoring, sensing the hazardous agents, and fighting against viruses and bacteria. Nano-silica sphere is an important member of the mesoporous family that noticeably flourished in biology, health care, and other industrial applications. Efficient one-pot multicomponent syntheses of 2-amino-3-cyano-4H-pyran derivatives were carried out over readily available and simply synthesized recyclable Hollow Mesoporous Silica Sphere (HMSS). Comparable yields were encountered with better efficiency, lower cost, and shorter reaction time. Hence, superior catalytic activity, flexibility, ease of recovery, tuneable hole size, and high surface to volume ratio were the major characteristics of the catalyst which distinguish this protocol from previously reported ones. The catalyst was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) techniques, and nitrogen absorption and desorption (BET) analyses. The results showed that the synthesizing of HMSS catalysts under a mild and green condition in which comparable yields were encountered with better efficiency, lower cost, and shorter reaction with other major economic advantages. © 2020 by the authors.
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