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The Role of Medicinal Products in the Treatment of Inflammatory Bowel Diseases (Ibd) Through Inhibition of Tlr4/Nf-Kappab Pathway Publisher Pubmed



Dejban P1, 2, 3 ; Nikravangolsefid N4 ; Chamanara M5 ; Dehpour A1, 2 ; Rashidian A1, 2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States
  4. 4. Faculty of medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2021


Abstract

Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll-like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines. © 2020 John Wiley & Sons Ltd
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