Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Mechanistic Review on Plant-Derived Natural Compounds As Dietary Supplements for Prevention of Inflammatory Bowel Disease Publisher Pubmed



Farzaei MH1, 2 ; Bahramsoltani R3 ; Abdolghaffari AH4, 5, 11 ; Sodagari HR6 ; Esfahani SA7 ; Rezaei N8, 9, 10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  5. 5. International Campus ICTUMS, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
  7. 7. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
  8. 8. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  11. 11. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

Source: Expert Review of Gastroenterology and Hepatology Published:2016


Abstract

ABSTRACT: Inflammatory bowel disease (IBD) is a recurrent idiopathic inflammatory condition, characterized by disruption of the gut mucosal barrier. This mechanistic review aims to highlight the significance of plant-derived natural compounds as dietary supplements, which can be used in addition to restricted conventional options for the prevention of IBD and induction of remission. Various clinical trials confirmed the effectiveness and tolerability of natural supplements in patients with IBD. Mounting evidence suggests that these natural compounds perform their protective and therapeutic effect on IBD through numerous molecular mechanisms, including anti-inflammatory and immunoregulatory, anti-oxidative stress, modulation of intracellular signaling transduction pathways, as well as improving gut microbiota. In conclusion, natural products can be considered as dietary supplements with therapeutic potential for IBD, provided that their safety and efficacy is confirmed in future well-designed clinical trials with adequate sample size. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease, Current Pharmaceutical Biotechnology (2015)
2. Dietary Anthocyanins As a Complementary Medicinal Approach for Management of Inflammatory Bowel Disease, Expert Review of Gastroenterology and Hepatology (2015)
3. Therapeutic Potential of Flavonoids in Inflammatory Bowel Disease: A Comprehensive Review, World Journal of Gastroenterology (2017)
4. Interventions of Natural and Synthetic Agents in Inflammatory Bowel Disease, Modulation of Nitric Oxide Pathways, World Journal of Gastroenterology (2020)
5. Role of Dietary Polyphenols in the Management of Peptic Ulcer, World Journal of Gastroenterology (2015)
6. Biochemical and Histopathological Evidence on the Beneficial Effects of Tragopogon Graminifolius in Tnbs-Induced Colitis, Pharmaceutical Biology (2015)
7. An Evidence-Based Review of Medicinal Plants Cited in Canon of Medicine for Management of Inflammatory Bowel Disease, Medicinal Plants used in Traditional Persian Medicine (2023)
8. Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases, Current Pharmaceutical Biotechnology (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (16)
Roja Rahimi (12)
Other Related Docs
9. The Emerging Microbiome-Based Approaches to Ibd Therapy: From Scfas to Urolithin A, Journal of Digestive Diseases (2022)
10. A Randomized, Double Blinded, Placebo-Controlled Clinical Trial of Silymarin in Ulcerative Colitis, Chinese Journal of Integrative Medicine (2015)
11. Phosalone-Induced Inflammation and Oxidative Stress in the Colon: Evaluation and Treatment, World Journal of Gastroenterology (2016)
12. Effects of Alpha Lipoic Acid and Its Derivative “Andrographolid-Lipoic Acid-1” on Ulcerative Colitis: A Systematic Review With Meta-Analysis of Animal Studies, Journal of Cellular Biochemistry (2019)
13. Dietary Intake of Fish, N-3 Polyunsaturated Fatty Acids, and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Observational Studies, European Journal of Nutrition (2020)
14. Consumption of Dairy Products and Odds of Ulcerative Colitis: An Iranian Case–Control Study, Food Science and Nutrition (2024)
15. Emerging Epidemic of Inflammatory Bowel Disease in a Middle Income Country: A Nation-Wide Study From Iran, Archives of Iranian Medicine (2016)
16. An Update on Dietary Consideration in Inflammatory Bowel Disease: Anthocyanins and More, Expert Review of Gastroenterology and Hepatology (2018)
17. Protective Effect of Freeze-Dried Extract of Persicaria Bistorta Samp. on Acetic Acid-Induced Colitis Model in Rats: Involvement of Nitric Oxide and Opioid System, Inflammopharmacology (2024)
18. Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: The Involvement of the Tlr4/Nf-Kb Signaling Pathway, Inflammation (2020)
19. Consumption of Rich/Enrich Phytonutrients Food and Their Relationship With Health Status of Population, Phytonutrients in Food: From Traditional to Rational Usage (2019)
20. Experimental and Pathalogical Study of Pistacia Atlantica, Butyrate, Lactobacillus Casei and Their Combination on Rat Ulcerative Colitis Model, Pathology Research and Practice (2016)
21. Immunomodulatory and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease (Ibd), Journal of Pharmacopuncture (2018)
22. Involvement of Pparγ in the Protective Action of Tropisetron in an Experimental Model of Ulcerative Colitis, Immunopharmacology and Immunotoxicology (2016)
23. Systematic Review and Meta-Analysis of the Incidence and Prevalence and 30-Year Trend of Inflammatory Bowel Diseases in Asia: A Study Protocol, BMJ Open (2019)
24. The Protective Effect of the Gallic Acid Against Tnbs-Induced Ulcerative Colitis in Rats: Role of Inflammatory Parameters, Journal of Iranian Medical Council (2018)
25. Ameliorative Effects of Standardized Extract of Tamarix Stricta Boiss. on Acetic Acid-Induced Colitis Via Modulating Nitrergic Pathways, Biologia (2022)
26. Dietary Patterns and Risk of Inflammatory Bowel Disease: A Systematic Review of Observational Studies, Inflammatory Bowel Diseases (2024)
27. Efficacy of Anti-Tnf Therapy for the Treatment of Patients With Moderate-To-Severe Inflammatory Bowel Disease; a First Iranian Report, Middle East Journal of Digestive Diseases (2020)
28. Lifestyle Alters Gut-Bacteria Function: Linking Immune Response and Host, Best Practice and Research: Clinical Gastroenterology (2017)
29. The Association Between Total Protein, Animal Protein, and Animal Protein Sources With Risk of Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Cohort Studies, Advances in Nutrition (2023)
30. Tea Polyphenols As Natural Products for Potential Future Management of Hiv Infection - an Overview, Journal of Natural Remedies (2016)
31. Early Onset Inflammatory Bowel Disease: Manifestations, Genetics and Diagnosis, Turkish Journal of Pediatrics (2019)
32. Anti-Inflammatory Effects of Ivermectin in the Treatment Of Acetic Acid-Induced Colitis in Rats: Involvement of Gabab Receptors, Digestive Diseases and Sciences (2022)
33. Iranian Association of Gastroenterology and Hepatology Position Statement in Management of Inflammatory Bowel Disease by Using Biological Drugs: Expert View; [بیانیه انجمن گوارش و کبد ایران در مورد مصرف داروهای بیولوژیک در بیماری هایالتهابی روده], Govaresh (2022)
34. Blood Regulatory T Cells in Inflammatory Bowel Disease, a Systematic Review, and Meta-Analysis, International Immunopharmacology (2023)
35. The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017, The Lancet Gastroenterology and Hepatology (2020)
36. A Mechanistic Review on Medicinal Plants Used for Rheumatoid Arthritis in Traditional Persian Medicine, Journal of Pharmacy and Pharmacology (2016)
37. The Preventive and Therapeutic Potential of Natural Polyphenols on Influenza, Expert Review of Anti-Infective Therapy (2016)
38. The Hydro-Alcoholic Extract of Achillea Wilhelmsii C. Koch Ameliorates Acetic Acid-Induced Ulcerative Colitis Through Tlr-4, Proceedings of the National Academy of Sciences India Section B - Biological Sciences (2023)
39. Natural Polyphenols for the Prevention of Irritable Bowel Syndrome: Molecular Mechanisms and Targets; a Comprehensive Review, DARU# Journal of Pharmaceutical Sciences (2019)
40. Dapsone Reduced Acetic Acid-Induced Inflammatory Response in Rat Colon Tissue Through Inhibition of Nf-Kb Signaling Pathway, Immunopharmacology and Immunotoxicology (2019)
41. Biochemical and Histopathological Evidence for the Beneficial Effects of Modafinil on the Rat Model of Inflammatory Bowel Disease: Involvement of Nitric Oxide Pathway, Pharmacological Reports (2020)
42. A Posteriori Dietary Patterns and Risk of Inflammatory Bowel Disease: A Meta-Analysis of Observational Studies, International Journal for Vitamin and Nutrition Research (2020)
43. Formulation, Standardization, and a Preliminary Before-After Clinical Trial on Effect of a Traditional Herbal Formula (Maqliasa) on Manifesta-Tions of Ulcerative Colitis, Current Drug Discovery Technologies (2021)
44. Mycobacterium Avium Subsp. Paratuberculosis and Associated Risk Factors for Inflammatory Bowel Disease in Iranian Patients, Gut Pathogens (2017)
45. Evaluating Macro- and Micronutrients and Food Groups Intake With the Risk of Developing Inflammatory Bowel Disease: Is There Any Association?, Food Science and Nutrition (2022)
46. Budesonide-Loaded Hyaluronic Acid Nanoparticles for Targeted Delivery to the Inflamed Intestinal Mucosa in a Rodent Model of Colitis, BioMed Research International (2022)
47. Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients With Inflammatory Bowel Diseases, Scandinavian Journal of Immunology (2017)
48. Promising Plant-Derived Secondary Metabolites for Treatment of Acne Vulgaris: A Mechanistic Review, Archives of Dermatological Research (2020)
49. Foeniculum Vulgare Essential Oil Ameliorates Acetic Acid-Induced Colitis in Rats Through the Inhibition of Nf-Kb Pathway, Inflammopharmacology (2018)
50. Administration of Dietary Antioxidants for Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Complementary Therapies in Medicine (2021)