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Genetic Susceptibility for Periodontitis With Special Focus on Immune-Related Genes: A Concise Review Publisher



Sayad A1, 2 ; Gholami L3 ; Mirzajani S2, 4 ; Omrani MD2 ; Ghafourifard S1 ; Taheri M5
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Periodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2020


Abstract

Periodontal disease (PD) is complex multifactorial disorder with high burden for health system. This disorder is caused by interaction of several genetic and environmental factors. About one third of the observed variance in the frequency of this condition is due to the genetic factors. Several genetic loci particularly in cytokine coding genes have been associated with risk of this disorder. CD14, IL-6, TNF-α, IL-10, IL-1 α and IL-1β have been among the mostly assessed genes in this regard. However, there is no consensus on association between a certain SNP and PD in different populations. In addition to these genes, GLT6D1, TENM2 and LDLRAD4 have been identified to be associated with PD through genome wide association studies. In the current review, we summarize the most important data about the role of genetic factors in PD. © 2020 Elsevier Inc.
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