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Emerging Role of Long Non-Coding Rnas in the Pathogenesis of Periodontitis Publisher Pubmed



Sayad A1 ; Mirzajani S1, 2 ; Gholami L3 ; Razzaghi P4 ; Ghafourifard S5 ; Taheri M6
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Periodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Student Research Committee, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2020


Abstract

Periodontitis is a bacteria-related chronic immune-associated condition that destructs bone and connective tissues around teeth. With a high incidence rate, it is regarded as a condition that impose substantial health burden. About half of the variance in the severity of periodontitis is attributed to genetic factors. Long non-coding RNAs (lncRNAs) have crucial roles in the development of several disorders such as periodontitis. A number of studies have reported dysregulation of lncRNAs such as UCA1, ANRIL, FGD5-AS1, NEAT1, FAS-AS1, Linc-RAM and NKILA in gingival tissues or blood samples of patients with periodontitis in comparison with healthy subjects. Moreover, several single nucleotide polymorphisms within lncRNAs have been associated with the susceptibility to this disorder. In the current review, we discuss the most recent articles about the role of lncRNAs in the pathogenesis of periodontitis. © 2020
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