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A Meta-Analysis on Association Between Viral Infections and Kawasaki Disease in Children Publisher



Farahmand M1 ; Ahmadivasmehjani A1 ; Esteghamati A2 ; Sayyahfar S2 ; Minaeian S3 ; Khanaliha K2 ; Naghdalipour M2 ; Tavakoli A2, 4
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  2. 2. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  3. 3. Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  4. 4. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran

Source: Future Virology Published:2021


Abstract

Aim: To investigate the association between different viral infections and the development of Kawasaki disease (KD) in children. Materials & methods: Electronic databases were searched for relevant studies published from inception to May 2020. The pooled odds ratios (ORs) of the association of different viral pathogens with KD were estimated using a random-effects model weighted by the inverse variance method. Results: The strongest associations were found between KD and human parvovirus B19 viremia (OR = 41.05; 95% CI: 5.13-328.28; I-square = 0%), EBV IgM seropositivity (OR = 7.18; 95% CI: 3.65-14.12, I-square = 0%) and human herpesvirus-6 IgG seropositivity (OR = 5.83; 95% CI: 1.06-32.01). Conclusion: Human parvovirus B19, EBV and human herpesvirus-6 are highly suspected to be key contributors to the development of KD. © 2021 Future Medicine Ltd.
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