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Effect of Vitamin a on Recovery From the Acute Phase of Multiple Sclerosis-Related Optic Neuritis, Double-Blind, Randomized, Placebo-Controlled Trial Publisher



Rahimidehgolan S1 ; Masoudi M1 ; Rahimidehgolan S1 ; Azimi AR1 ; Sahraian MA1 ; Baghbanian SM3 ; Moghadasi AN1
Authors
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Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran
  2. 2. Physical Medicine and Rehabilitation Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Caspian Journal of Internal Medicine Published:2023


Abstract

Background: Optic neuritis (ON) is one of the main neuro-ophthalmic presentations of multiple sclerosis (MS), and it causes optic nerve atrophy and axonal loss. However, so far, there is no effective treatment to improve long-term outcomes. Methods: In a double-blind placebo-controlled randomized clinical trial, 50 patients with MS-related ON were allocated into two arms (24 in the control group and 26 in the intervention group) receiving either 25000IU retinyl palmitate or an identical placebo for six months. Visual evoked potential (VEP), visual acuity, and the retinal nerve fiber layer (RNFL) thickness were evaluated and compared before and after the treatment. Results: RNFL thickness reduction in the affected eyes at sixth month compared to the baseline were 14.81 and 19.46 μm, in the intervention and control groups, respectively (P=0.017). However, VitA therapy did not affect visual acuity and VEP. Conclusion: Vitamin A supplementation in the patients with acute ON in MS could lessen optic nerve axonal loss. © The Author(s)
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