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The Role of Cerebellar Abnormalities in Neuromyelitis Optica - a Comparison With Multiple Sclerosis and Healthy Controls Publisher Pubmed



Weier K1 ; Eshaghi A2 ; Magon S1 ; Andelova M1 ; Radue EW3 ; Kappos L1 ; Azimi AR2 ; Sahraian MA2 ; Sprenger T4
Authors
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Authors Affiliations
  1. 1. Department of Neurology, University Hospital Basel, Petersgraben 4, Basel, 4031, Switzerland
  2. 2. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Image Analysis Center (MIAC) AG, C/o University Hospital Basel, Switzerland
  4. 4. Department of Radiology and Nuclear Medicine, Division of Neuroradiology, University Hospital Basel, Switzerland

Source: Multiple Sclerosis Published:2015


Abstract

Background: In relapsingremitting multiple sclerosis (RRMS), the cerebellum is a known predilection site for atrophy. Neuromyelitis optica (NMO) is characterized by extensive lesions in the spinal cord and optic nerve; however, cerebellar involvement has been less studied. Secondary degeneration of the spinocerebellar tract could impact the cerebellum in NMO. Objective: We aimed to investigate whether spinal cord and cerebellar volume measures differ between patients with NMO and RRMS. Methods: Volumetric analyses of the cerebellum (TCV), the upper cervical cord (UCV) as well as the whole brain (NBV) of age- and gender-matched patients with NMO (n=30; 56% AQP4 +ve) and RRMS (n=25) were performed on 3T brain magnetic resonance imaging (MRI) and compared with 34 healthy controls (HC). Results: UCV was significantly reduced in NMO patients (6.3 cm3) as compared with HC (6.7 cm3), while patients with MS had reduced brain volumes compared with HC (NBV=1482 cm3; p<0.001; TCV=188 cm3; p=0.042), but UCV close to normal values. Patients with RRMS and NMO differed in NBV (p=0.001; lower in RRMS) and by trend (towards reduction in RRMS) in cerebellar volume (p=0.06). Conclusions: While atrophy seems to be diffuse in MS patients, a rather focussed pattern with predominant involvement of the UCV was observed in NMO patients. © The Author(s), 2014.
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