Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds

Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds Publisher Pubmed

Jalilibaleh L¹ ; Forootanfar H² ; Kucukkilinc TT³ ; Nadri H⁴ ; Abdolahi Z⁴ ; Ameri A⁵ ; Jafari M² ; Ayazgok B³ ; Baeeri M¹ ; Rahimifard M¹ ; Abbas Bukhari SN⁶ ; Abdollahi M¹ ; Ganjali MR^{7, 8} ; Emami S⁹ Show All Authors

Jalilibaleh L¹
Forootanfar H²
Kucukkilinc TT³
Nadri H⁴
Abdolahi Z⁴
Ameri A⁵
Jafari M²
Ayazgok B³
Baeeri M¹
Rahimifard M¹
Abbas Bukhari SN⁶
Abdollahi M¹
Ganjali MR^{7, 8}
Emami S⁹
Khoobi M^{1, 10}
Foroumadi A¹¹

Source: European Journal of Medicinal Chemistry Published:2018

Abstract

A novel series of coumarin-lipoic acid conjugates were synthesized via cycloaddition click reaction to find out new multi-target-directed ligands (MTDLs) for treatment of Alzheimer's disease (AD). All of synthesized compounds were screened for neuroprotective and anti-cholinesterase activities. Based on primary screening, two compounds (5 and 11) were subjected to further biological evaluations. In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Aβ-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Aβ1-42-induced cytotoxicity. In the light of these results, the applied hybridization approach introduced new promising lead compound with desired multifunctional properties, being useful in the treatment of Alzheimer's disease. © 2018 Elsevier Masson SAS

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Alireza Foroumadi (16)

Mehdi Khoobi (13)

Style	Citing Format
MLA	Jalilibaleh L, et al.. "Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds." European Journal of Medicinal Chemistry, vol. 152, no. , 2018, pp. 600-614.
APA	Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, Ayazgok B, Baeeri M, Rahimifard M, Abbas Bukhari SN, Abdollahi M, Ganjali MR, Emami S, Khoobi M, Foroumadi A (2018). Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds. European Journal of Medicinal Chemistry, 152(), 600-614.
Chicago	Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, et al.. "Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds." European Journal of Medicinal Chemistry 152, no. (2018): 600-614.
Harvard	Jalilibaleh L et al. (2018) 'Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds', European Journal of Medicinal Chemistry, 152(), pp. 600-614.
Vancouver	Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, et al.. Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds. European Journal of Medicinal Chemistry. 2018;152():600-614.
BibTex	@article{ author = {Jalilibaleh L and Forootanfar H and Kucukkilinc TT and Nadri H and Abdolahi Z and Ameri A and Jafari M and Ayazgok B and Baeeri M and Rahimifard M and Abbas Bukhari SN and Abdollahi M and Ganjali MR and Emami S and Khoobi M and Foroumadi A}, title = {Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds}, journal = {European Journal of Medicinal Chemistry}, volume = {152}, number = {}, pages = {600-614}, year = {2018} }
RIS	TY - JOUR AU - Jalilibaleh L AU - Forootanfar H AU - Kucukkilinc TT AU - Nadri H AU - Abdolahi Z AU - Ameri A AU - Jafari M AU - Ayazgok B AU - Baeeri M AU - Rahimifard M AU - Abbas Bukhari SN AU - Abdollahi M AU - Ganjali MR AU - Emami S AU - Khoobi M AU - Foroumadi A TI - Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds JO - European Journal of Medicinal Chemistry VL - 152 IS - SP - 600 EP - 614 PY - 2018 ER -

Style

Citing Format

MLA

Jalilibaleh L, et al.. "Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds." European Journal of Medicinal Chemistry, vol. 152, no. , 2018, pp. 600-614.

APA

Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, Ayazgok B, Baeeri M, Rahimifard M, Abbas Bukhari SN, Abdollahi M, Ganjali MR, Emami S, Khoobi M, Foroumadi A (2018). Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds. European Journal of Medicinal Chemistry, 152(), 600-614.

Chicago

Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, et al.. "Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds." European Journal of Medicinal Chemistry 152, no. (2018): 600-614.

Harvard

Jalilibaleh L et al. (2018) 'Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds', European Journal of Medicinal Chemistry, 152(), pp. 600-614.

Vancouver

Jalilibaleh L, Forootanfar H, Kucukkilinc TT, Nadri H, Abdolahi Z, Ameri A, et al.. Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds. European Journal of Medicinal Chemistry. 2018;152():600-614.

BibTex

@article{ author = {Jalilibaleh L and Forootanfar H and Kucukkilinc TT and Nadri H and Abdolahi Z and Ameri A and Jafari M and Ayazgok B and Baeeri M and Rahimifard M and Abbas Bukhari SN and Abdollahi M and Ganjali MR and Emami S and Khoobi M and Foroumadi A}, title = {Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds}, journal = {European Journal of Medicinal Chemistry}, volume = {152}, number = {}, pages = {600-614}, year = {2018} }

RIS

TY - JOUR
AU - Jalilibaleh L
AU - Forootanfar H
AU - Kucukkilinc TT
AU - Nadri H
AU - Abdolahi Z
AU - Ameri A
AU - Jafari M
AU - Ayazgok B
AU - Baeeri M
AU - Rahimifard M
AU - Abbas Bukhari SN
AU - Abdollahi M
AU - Ganjali MR
AU - Emami S
AU - Khoobi M
AU - Foroumadi A
TI - Design, Synthesis and Evaluation of Novel Multi-Target-Directed Ligands for Treatment of Alzheimer's Disease Based on Coumarin and Lipoic Acid Scaffolds
JO - European Journal of Medicinal Chemistry
VL - 152
IS -
SP - 600
EP - 614
PY - 2018
ER -

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Abstract