A Review on Flavonoid-Based Scaffolds As Multi-Target-Directed Ligands (Mtdls) for Alzheimer's Disease Publisher Pubmed



Jalilibaleh L¹ ; Babaei E² ; Abdpour S³ ; Nasir Abbas Bukhari S⁴ ; Foroumadi A^{1, 5} ; Ramazani A³ ; Sharifzadeh M⁶ ; Abdollahi M¹ ; Khoobi M^{1, 7}
Source: European Journal of Medicinal Chemistry Published:2018

Abstract

Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta-secretase, monoamine oxidase and inhibition of amyloid-β aggregation as well as oxidative stress and metal chelation play an important role in the pathogenesis of AD. Chroman-4-one scaffold with benzo-γ-pyrone network is a privileged structure in organic synthesis and drug design. A large number of research has been carried out on modified naturally occurring chromanone scaffolds and/or synthesized new analogues, to obtain effective drugs for AD management. The present review summarizes aspects related to the multi-target-directed ligands (MTDLs) strategy in enzyme targets modulation performed with natural and synthesized chroman-4-one-based structures to look at their potential in the management of multifactorial Alzheimer's disease. © 2018 Elsevier Masson SAS