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A Review on Flavonoid-Based Scaffolds As Multi-Target-Directed Ligands (Mtdls) for Alzheimer's Disease Publisher Pubmed



Jalilibaleh L1 ; Babaei E2 ; Abdpour S3 ; Nasir Abbas Bukhari S4 ; Foroumadi A1, 5 ; Ramazani A3 ; Sharifzadeh M6 ; Abdollahi M1 ; Khoobi M1, 7
Authors
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Authors Affiliations
  1. 1. The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Chemistry, Faculty of science, Yazd University, Yazd, Iran
  3. 3. Department of Chemistry, University of Zanjan, Zanjan, Iran
  4. 4. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Saudi Arabia
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Toxicology and poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Medicinal Chemistry Published:2018


Abstract

Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta-secretase, monoamine oxidase and inhibition of amyloid-β aggregation as well as oxidative stress and metal chelation play an important role in the pathogenesis of AD. Chroman-4-one scaffold with benzo-γ-pyrone network is a privileged structure in organic synthesis and drug design. A large number of research has been carried out on modified naturally occurring chromanone scaffolds and/or synthesized new analogues, to obtain effective drugs for AD management. The present review summarizes aspects related to the multi-target-directed ligands (MTDLs) strategy in enzyme targets modulation performed with natural and synthesized chroman-4-one-based structures to look at their potential in the management of multifactorial Alzheimer's disease. © 2018 Elsevier Masson SAS
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