Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats

Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats Publisher Pubmed

Sajadi A¹ ; Amiri I^{2, 3} ; Gharebaghi A¹ ; Komaki A¹ ; Asadbeigi M¹ ; Shahidi S¹ ; Mehdizadeh M⁴ ; Soleimani Asl S^{1, 2}

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1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2. Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3. Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4. Cellular and Molecular Research Center, Faculty of Advanced Technologies in Medicine, Department of Anatomy, Iran University of Medical sciences, Tehran, Iran

Source: Metabolic Brain Disease Published:2017

Abstract

3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy is a derivative of amphetamine that leads to long term potentiation (LTP) disruption in the hippocampal dentate gyrus (DG). Exercise has been accepted as a treatment for the improvement of neurodegenerative disease. Herein, the effects of exercise on the MDMA- induced neurotoxicity were assessed. Male Wistar rats received intraperitoneal injection of MDMA (10 mg/kg) and exercised for one month on a treadmill (Simultaneously or asynchronously with MDMA). LTP and expression of BDNF were assessed using electrophysiology and western blotting methods, respectively. MDMA attenuated the field excitatory post-synaptic potential (fEPSP) slope in comparison with the control group, whereas treadmill exercise increased this parameter when compared to MDMA group. Furthermore, BDNF expression significantly decreased in MDMA group and treadmill exercise could increase that. In conclusion, results of this study suggest that synchronous exercise is able to improve MDMA-induced LTP changes through increase of BDNF expression in the hippocampus of rats. © 2017, Springer Science+Business Media, LLC.

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Style	Citing Format
MLA	Sajadi A, et al.. "Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats." Metabolic Brain Disease, vol. 32, no. 5, 2017, pp. 1603-1607.
APA	Sajadi A, Amiri I, Gharebaghi A, Komaki A, Asadbeigi M, Shahidi S, Mehdizadeh M, Soleimani Asl S (2017). Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats. Metabolic Brain Disease, 32(5), 1603-1607.
Chicago	Sajadi A, Amiri I, Gharebaghi A, Komaki A, Asadbeigi M, Shahidi S, Mehdizadeh M, Soleimani Asl S. "Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats." Metabolic Brain Disease 32, no. 5 (2017): 1603-1607.
Harvard	Sajadi A et al. (2017) 'Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats', Metabolic Brain Disease, 32(5), pp. 1603-1607.
Vancouver	Sajadi A, Amiri I, Gharebaghi A, Komaki A, Asadbeigi M, Shahidi S, et al.. Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats. Metabolic Brain Disease. 2017;32(5):1603-1607.
BibTex	@article{ author = {Sajadi A and Amiri I and Gharebaghi A and Komaki A and Asadbeigi M and Shahidi S and Mehdizadeh M and Soleimani Asl S}, title = {Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats}, journal = {Metabolic Brain Disease}, volume = {32}, number = {5}, pages = {1603-1607}, year = {2017} }
RIS	TY - JOUR AU - Sajadi A AU - Amiri I AU - Gharebaghi A AU - Komaki A AU - Asadbeigi M AU - Shahidi S AU - Mehdizadeh M AU - Soleimani Asl S TI - Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats JO - Metabolic Brain Disease VL - 32 IS - 5 SP - 1603 EP - 1607 PY - 2017 ER -

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