Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Research Paper: The Effects of 3,4-Methylenedioxy-Methamphetamine on Neurogenesis in the Hippocampus of Male Rats Publisher



Asl SS1 ; Moravej FG1 ; Kowsari G2 ; Farhadi MH3 ; Pourhaydar B4 ; Hamidabadi HG5 ; Mehdizadeh M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Researcher of Subsance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  4. 4. Department of Anatomy, Neurophysiology Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  5. 5. Department of Anatomy and Cell Biology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Department of Anatomy, Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Basic and Clinical Neuroscience Published:2020


Abstract

Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells. © 2020 Iran University of Medical Sciences. All rights reserved.
Related Docs
1. Treadmill Exercise Alters Ecstasy- Induced Long- Term Potentiation Disruption in the Hippocampus of Male Rats, Metabolic Brain Disease (2017)
2. Treadmill Exercise Attenuates 3,4-Methylenedioxymethamphetamine-Induced Memory Impairment Through a Decrease Apoptosis in Male Rat Hippocampus, Journal of Neuroscience Research (2017)
3. Hippocampal Nicotinic Receptors Have a Modulatory Role for Ethanol and Mdma Interaction in Memory Retrieval, Brain Research (2017)