Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Oral Consumption of Honey on Key Metabolic Profiles in Adult Patients With Type 2 Diabetes Mellitus and Nondiabetic Individuals: A Systematic Review of Clinical Trials Publisher



Akhbari M1 ; Jabbari M2 ; Ayati MH1, 3, 4 ; Namazi N5
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Industry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of History of Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Evidence-based Complementary and Alternative Medicine Published:2021


Abstract

Objectives. Although several clinical trials have revealed the beneficial effects of honey on metabolic profiles, the results are conflicting. The aim of this study was to systematically summarize the effects of oral consumption of honey on key metabolic profiles in adult patients with type 2 diabetes mellitus (T2DM) and nondiabetic individuals. Methods. In total, four electronic databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane library, were searched from 2000 to 31 July 2019 to identify all English language studies that would meet the eligibility criteria. Clinical trials which have examined the effects of oral consumption of any types of honey on anthropometric indices, glycemic status, lipid profiles, and blood pressure in both diabetic and nondiabetic adult subjects were included in the study. Results. Of the 7769 possible relevant studies (including 3547 duplicates) identified in the initial search, finally, 13 clinical trials were included in the systematic review. All studies except three had a parallel design. Of 13 studies, 8 trials did not have placebo/control groups. The included studies examined the impact of oral consumption of honey on glycemic status (n = 12), anthropometric indices (n = 6), lipid profiles (n = 10), and blood pressure (n = 3). Based on the Jadad scale, 5 studies had acceptable methodological quality, and the remaining (n = 8) had low methodological quality. Conclusion. The current systematic review showed that oral consumption of honey might have no significant effects on the modulation of metabolic profiles in nondiabetic subjects. In addition, a high intake of honey might increase glucose levels and worsen other metabolic parameters in patients with T2DM. Due to substantial heterogeneity in study design and limited clinical trials, results, however, should be interpreted with great caution. © 2021 Marzieh Akhbari et al.
Related Docs
1. The Role of Honey in Reproductive Age Gynecological Diseases: An Overview of Clinical Trials, Traditional and Integrative Medicine (2024)
2. Characterization and Classification of Iranian Honey Based on Physicochemical Properties and Antioxidant Activities, With Chemometrics Approach, Iranian Journal of Pharmaceutical Research (2018)
3. Natural Fruits, Flowers, Honey, and Honeybees Harbor Helicobacter Pylori-Positive Yeasts, Helicobacter (2018)
Experts (# of related papers)
Mohammad Reza Khoshayand (1)
Masoud Yunesian (1)