Short-Term Effect of Gluten-Free Diet on Disease Severity, Quality of Life, and Inflammatory Markers Among Patients With Mild to Moderate Ulcerative Colitis: A Triple-Blind Randomized Placebo-Controlled Trial Publisher



Alborzi Avanaki F^{1, 3} ; Ebrahimi Daryani N¹ ; Aletaha N¹ ; Hesabgar N¹ ; Rezaeezavareh MS² ; Hadi R¹ Show Affiliations
Source: Arab Journal of Gastroenterology Published:2024

Abstract

Background and study aims: Diet is an important underlying factor in ulcerative colitis (UC) disease. The present study aimed to investigate the effect of a gluten-free diet (GFD) on disease severity, quality of life, and inflammatory markers in patients with UC. Patients and Methods: In this triple-blind randomized placebo-controlled clinical trial, we evaluated the effect of a GFD on the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fecal calprotectin, disease severity, and quality of life in patients with mild to moderate UC. Patients’ quality of life and severity of symptoms were evaluated using the Inflammatory Bowel Disease Questionnaire (IBDQ) and Simple Clinical Colitis Activity Index (SCCAI), respectively. Patients received this regimen for six weeks and were evaluated before and after the intervention. Results: The mean age of patients (n = 26) was 39.31 years (standard deviation = 9.34). In both study groups, the mean ESR, CRP, IBDQ, and SCCAI showed no statistically significant improvement with the dietary intervention. Fecal calprotectin was increased in both groups without statistical significance. Conclusions: We could not find any significant effect of GFD on inflammatory markers, quality of life, and disease severity among patients with mild to moderate UC. It is too early to suggest the gluten-free diet as a safe and beneficial regimen for UC patients. There is a need for further investigations with larger sample sizes and longer follow-ups as clinical trials and cohort studies to obtain more reliable results. © 2024 Pan-Arab Association of Gastroenterology