The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial

The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial Publisher Pubmed

Mohseni F¹ ; Agah S² ; Ebrahimidaryani N³ ; Taher M³ ; Nattagheshtivani E⁴ ; Karimi S³ ; Rastgoo S¹ ; Bourbour F¹ ; Hekmatdoost A¹

Show Affiliations

1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
3. Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran
4. Students Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Clinical Nutrition ESPEN Published:2022

Abstract

Background & aim: Although the effects of low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet on amelioration of irritable bowel syndrome (IBS) symptoms have been reported previously, it has not yet been elucidated whether the gluten of wheat and barley induces the symptoms or only their fructans lead to aggravation of the symptoms. The aim of this study was to assess the effect of low FODMAPs diet with vs. without gluten on clinical symptoms in IBS patients. Methods: In this double-blind, placebo-controlled randomized trial, forty nine IBS patients were randomly assigned to placebo and/or intervention group. Patients in the intervention group received 5 gr/day of gluten powder with low FODMAP diet, while placebo group received 5 gr of rice flour as placebo, with low FODMAP diet. Quality of life (QoL) and IBS-SSS (symptom severity score) were measured before and after the intervention using a valid QoL questionnaire and a standard visual analog scale, respectively. Results: Significant improvements were observed in total scores of IBS-SSS (−32% vs. – 49%), abdominal pain intensity (−45% vs. −52%), and frequency (−26 vs. −46%), abdominal distension (−29% vs. −63%), Interference with community function (−14% vs. −45%) and quality of life (+23 vs. +32%) in both gluten and placebo groups respectively (P < 0.05). Only 5 patients in the gluten-containing diet reported exacerbation of their symptoms. Conclusion: Exacerbation of IBS symptoms after wheat and barley consumption is due to their fructan, and not related to their gluten content in most of the patients. Clinical trial registration no: IRCT20100524004010N29. © 2021 European Society for Clinical Nutrition and Metabolism

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Style	Citing Format
MLA	Mohseni F, et al.. "The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial." Clinical Nutrition ESPEN, vol. 47, no. , 2022, pp. 45-50.
APA	Mohseni F, Agah S, Ebrahimidaryani N, Taher M, Nattagheshtivani E, Karimi S, Rastgoo S, Bourbour F, Hekmatdoost A (2022). The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial. Clinical Nutrition ESPEN, 47(), 45-50.
Chicago	Mohseni F, Agah S, Ebrahimidaryani N, Taher M, Nattagheshtivani E, Karimi S, Rastgoo S, Bourbour F, Hekmatdoost A. "The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial." Clinical Nutrition ESPEN 47, no. (2022): 45-50.
Harvard	Mohseni F et al. (2022) 'The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial', Clinical Nutrition ESPEN, 47(), pp. 45-50.
Vancouver	Mohseni F, Agah S, Ebrahimidaryani N, Taher M, Nattagheshtivani E, Karimi S, et al.. The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial. Clinical Nutrition ESPEN. 2022;47():45-50.
BibTex	@article{ author = {Mohseni F and Agah S and Ebrahimidaryani N and Taher M and Nattagheshtivani E and Karimi S and Rastgoo S and Bourbour F and Hekmatdoost A}, title = {The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial}, journal = {Clinical Nutrition ESPEN}, volume = {47}, number = {}, pages = {45-50}, year = {2022} }
RIS	TY - JOUR AU - Mohseni F AU - Agah S AU - Ebrahimidaryani N AU - Taher M AU - Nattagheshtivani E AU - Karimi S AU - Rastgoo S AU - Bourbour F AU - Hekmatdoost A TI - The Effect of Low Fodmap Diet With and Without Gluten on Irritable Bowel Syndrome: A Double Blind, Placebo Controlled Randomized Clinical Trial JO - Clinical Nutrition ESPEN VL - 47 IS - SP - 45 EP - 50 PY - 2022 ER -

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