Association Between Rs3088440 (G > A) Polymorphism at 9P21.3 Locus With the Occurrence and Severity of Coronary Artery Disease in an Iranian Population Publisher Pubmed



Pourgholi M^{1, 2} ; Abazari O³ ; Pourgholi L⁴ ; Ghasemikasman M⁵ ; Boroumand M⁴ Show Affiliations
Source: Molecular Biology Reports Published:2021

Abstract

Background: Several genome-wide association studies showed that a series of genetic variants located at the chromosome 9p21 locus are strongly associated with coronary artery disease (CAD). Rationale and purpose of the study: In the present study, the relationship of rs3088440 (G > A) in cyclin-dependent kinase inhibitor 2A (CDKN2A) gene site with the presence of coronary artery disease (CAD) and its severity was evaluated in an Iranian population. Methods and results: The presence of rs3088440 (G > A) genotypes was assessed by polymerase chain reaction-based restriction fragment length polymorphism (PCR–RFLP) technique in 324 CAD patients and 148 normal controls. rs3088440 (G > A) polymorphism was associated with increased risk of CAD in the total population (adjusted OR = 1.76, 95% CI = 1.10–2.82; p-value = 0.017) or in women (adjusted OR = 2.96, 95% CI = 1.34–6.55; p-value = 0.007), but not in the men (adjusted OR = 1.35, 95% CI = 0.70–2.6; p-value = 0.368). Conclusions: Our findings suggest that the presence of rs3088440 (G > A) is potentially linked with the risk of CAD and its severity in whole study subjects or in women only, independent of CAD risk factors. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.