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Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Fibrin Glue for Periodontal Regeneration Publisher Pubmed



Rezaei M1 ; Jamshidi S2 ; Saffarpour A3 ; Ashouri M4 ; Rahbarghazi R5 ; Rokn AR6 ; Motahari P4
Authors
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Authors Affiliations
  1. 1. Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University, Kerman, Iran
  2. 2. Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  3. 3. Department of Periodontology, School of Dentistry, Tehran University of Medical Sciences International Campus, Tehran, Iran
  4. 4. Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahed University of Medical Sciences, Tehran, Iran
  5. 5. Department of Applied Cell Sciences, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Dental Implant Research Center and Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Periodontics and Restorative Dentistry Published:2019


Abstract

Appropriate regeneration of periodontal tissues is the primary purpose of periodontal disease treatment. The present study assessed the impact of three key regenerative elements-platelet-rich plasma (PRP), canine bone marrow mesenchymal stem cells (cBM-MSCs), and fibrin glue-on periodontal regeneration. In each of the study's five dogs, Class II furcation defects were established on the buccal surface of five teeth. One tooth (five total) from each dog was placed into one of five groups: (1) PRP + fibrin glue, (2) PRP + fibrin glue + cBM-MSCs, (3) fibrin glue, (4) cBM-MSCs + fibrin glue, and (5) control (no treatment). Histologic and histometric evaluations were performed to assess the formation of new bone, cementum, and the periodontal ligament. Different types of new bone and cementum, the maximum thickness of new cementum and the periodontal ligament (PDL), the vitality of bone, and the presence of inflammation or foreign-body reactions were also elucidated. The histologic and histometric evaluations revealed substantial differences in all groups between the observed maximum thickness of newly formed cementum and PDL. The percentage of bone and cement formation drastically increased with the combined presence of stem cells, fibrin glue, and PRP. The results showed that the inherent regenerative capacity of periodontal tissues can be sufficient if their latent self-repair mechanisms are stimulated. © 2019 by Quintessence Publishing Co Inc.
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