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Potential Application of Picosecond Pulsed Electric Field (Ppef): Advanced Bioelectrical Technology for Potential Covid-19 Treatment Publisher



Farmani AR1, 2 ; James Swanson R3 ; Mahdavinezhad F4 ; Shoormeij MH5 ; Mohammadi S6 ; Moeinzadeh A7, 8 ; Ghazipour F9 ; Ai J1
Authors
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Authors Affiliations
  1. 1. Tissue Engineering and Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Anatomical Sciences, College of Osteopathic Medicine, Liberty University, Lynchburg, VA, United States
  4. 4. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Emergency Medicine Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Plastic Engineering, Faculty of Polymer Processing, Iran Polymer and Petrochemical Institute, Tehran, Iran
  7. 7. Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of New Materials for Electrochemical Systems Published:2021


Abstract

As human knowledge has increased, the efficacy and precision of tools to solve clinical problems have also increased. The challenge of COVID-19 has posed a significant threat to human life and reflects the need to upgrade existing technologies and make treatments more precise. Since the corona virus particle is in the nanometer range, the need for a device with accuracy beyond the nanometer range is apparent to control and eliminate it. Using Picosecond Pulsed Electric Fields (PPEF) could be a good antiviral picotechnology candidate. PPEF energy can (1) increase the innate immunity function of polymorphonuclear neutrophils, (2) destroy bacteria and other pathogens, and (3) potentially inactivate viral particles. This characteristic of PPEFs has already been used in the food industry. Both PPEF and nanosecond PEF technology is being used to treat cancer in research animals and has reached the stage of pre-clinical and clinical human trials with use in clinical practice soon to follow. Applying advanced PPEF technology against COVID-19 should provide new opportunities for effective human antiviral treatment. © 2021 Ecole Polytechnique de Montreal. All rights reserved.
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