Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia

Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia Publisher

Zhang Q^{1, 2, 3} ; Matuozzo D^{2, 3} ; Le Pen J⁴ ; Lee D^{1, 2, 3} ; Moens L⁴ ; Asano T¹ ; Bohlen J^{2, 3} ; Liu Z¹ ; Moncadavelez M¹ ; Kendirdemirkol Y¹ ; Jing H⁶ ; Bizien L^{2, 3} ; Marchal A^{2, 3} ; Abolhassani H^{7, 8} Show All Authors

Zhang Q^{1, 2, 3}
Matuozzo D^{2, 3}
Le Pen J⁴
Lee D^{1, 2, 3}
Moens L⁴
Asano T¹
Bohlen J^{2, 3}
Liu Z¹
Moncadavelez M¹
Kendirdemirkol Y¹
Jing H⁶
Bizien L^{2, 3}
Marchal A^{2, 3}
Abolhassani H^{7, 8}
Delafontaine S^{5, 9}
Bucciol G⁵
Bayhan GI¹⁰
Keles S¹¹
Kiykim A¹²
Hancerli S¹³
Haerynck F¹⁴
Florkin B¹⁵
Hatipoglu N¹⁶
Ozcelik T¹⁷
Morelle G¹⁸
Zatz M¹⁹
Ng LFP²⁰
Lye DC^{21, 22, 23, 24}
Young BE^{21, 23, 24}
Leo YS^{21, 22, 23, 24}
Dalgard CL^{25, 26}
Lifton RP^{27, 28, 29}
Renia L^{20, 23, 30}
Meyts I⁵
Jouanguy E^{1, 2, 3}
Hammarstrom L⁷
Panhammarstrom Q⁷
Boisson B^{1, 2, 3}
Bastard P^{1, 2, 3, 31}
Su HC⁶
Boissondupuis S^{1, 2, 3}
Abel L^{1, 2, 3}
Rice CM⁴
Zhang SY^{1, 2, 3}
Cobat A^{1, 2, 3}
Casanova JL^{1, 2, 3, 31, 32}

Source: Journal of Experimental Medicine Published:2022

Abstract

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (<16 yr old) hospitalized for COVID-19 pneumonia, we report 12 children (10.7%) aged 1.5–13 yr with critical (7 children), severe (3), and moderate (2) pneumonia and 4 of the 15 known clinically recessive and biochemically complete inborn errors of type I IFN immunity: X-linked recessive TLR7 deficiency (7 children) and autosomal recessive IFNAR1 (1), STAT2 (1), or TYK2 (3) deficiencies. Fibroblasts deficient for IFNAR1, STAT2, or TYK2 are highly vulnerable to SARS-CoV-2. These 15 deficiencies were not found in 1,224 children and adults with benign SARS-CoV-2 infection without pneumonia (P = 1.2 × 10−11) and with overlapping age, sex, consanguinity, and ethnicity characteristics. Recessive complete deficiencies of type I IFN immunity may underlie ∼10% of hospitalizations for COVID-19 pneumonia in children. © 2022 Zhang et al.

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Style	Citing Format
MLA	Zhang Q, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine, vol. 219, no. 8, 2022, pp. -.
APA	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncadavelez M, Kendirdemirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, Bayhan GI, Keles S, Kiykim A, ... Casanova JL (2022). Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine, 219(8), -.
Chicago	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine 219, no. 8 (2022): -.
Harvard	Zhang Q et al. (2022) 'Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia', Journal of Experimental Medicine, 219(8), pp. -.
Vancouver	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, et al.. Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine. 2022;219(8):-.
BibTex	@article{ author = {Zhang Q and Matuozzo D and Le Pen J and Lee D and Moens L and Asano T and Bohlen J and Liu Z and Moncadavelez M and Kendirdemirkol Y and Jing H and Bizien L and Marchal A and Abolhassani H and Delafontaine S and Bucciol G and Bayhan GI and Keles S and Kiykim A and Hancerli S and Haerynck F and Florkin B and Hatipoglu N and Ozcelik T and Morelle G and Zatz M and Ng LFP and Lye DC and Young BE and Leo YS and Dalgard CL and Lifton RP and Renia L and Meyts I and Jouanguy E and Hammarstrom L and Panhammarstrom Q and Boisson B and Bastard P and Su HC and Boissondupuis S and Abel L and Rice CM and Zhang SY and Cobat A and Casanova JL}, title = {Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia}, journal = {Journal of Experimental Medicine}, volume = {219}, number = {8}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zhang Q AU - Matuozzo D AU - Le Pen J AU - Lee D AU - Moens L AU - Asano T AU - Bohlen J AU - Liu Z AU - Moncadavelez M AU - Kendirdemirkol Y AU - Jing H AU - Bizien L AU - Marchal A AU - Abolhassani H AU - Delafontaine S AU - Bucciol G AU - Bayhan GI AU - Keles S AU - Kiykim A AU - Hancerli S AU - Haerynck F AU - Florkin B AU - Hatipoglu N AU - Ozcelik T AU - Morelle G AU - Zatz M AU - Ng LFP AU - Lye DC AU - Young BE AU - Leo YS AU - Dalgard CL AU - Lifton RP AU - Renia L AU - Meyts I AU - Jouanguy E AU - Hammarstrom L AU - Panhammarstrom Q AU - Boisson B AU - Bastard P AU - Su HC AU - Boissondupuis S AU - Abel L AU - Rice CM AU - Zhang SY AU - Cobat A AU - Casanova JL TI - Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia JO - Journal of Experimental Medicine VL - 219 IS - 8 SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Zhang Q, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine, vol. 219, no. 8, 2022, pp. -.

APA

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncadavelez M, Kendirdemirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, Bayhan GI, Keles S, Kiykim A, ... Casanova JL (2022). Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine, 219(8), -.

Chicago

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine 219, no. 8 (2022): -.

Harvard

Zhang Q et al. (2022) 'Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia', Journal of Experimental Medicine, 219(8), pp. -.

Vancouver

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, et al.. Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine. 2022;219(8):-.

BibTex

@article{ author = {Zhang Q and Matuozzo D and Le Pen J and Lee D and Moens L and Asano T and Bohlen J and Liu Z and Moncadavelez M and Kendirdemirkol Y and Jing H and Bizien L and Marchal A and Abolhassani H and Delafontaine S and Bucciol G and Bayhan GI and Keles S and Kiykim A and Hancerli S and Haerynck F and Florkin B and Hatipoglu N and Ozcelik T and Morelle G and Zatz M and Ng LFP and Lye DC and Young BE and Leo YS and Dalgard CL and Lifton RP and Renia L and Meyts I and Jouanguy E and Hammarstrom L and Panhammarstrom Q and Boisson B and Bastard P and Su HC and Boissondupuis S and Abel L and Rice CM and Zhang SY and Cobat A and Casanova JL}, title = {Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia}, journal = {Journal of Experimental Medicine}, volume = {219}, number = {8}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Zhang Q
AU - Matuozzo D
AU - Le Pen J
AU - Lee D
AU - Moens L
AU - Asano T
AU - Bohlen J
AU - Liu Z
AU - Moncadavelez M
AU - Kendirdemirkol Y
AU - Jing H
AU - Bizien L
AU - Marchal A
AU - Abolhassani H
AU - Delafontaine S
AU - Bucciol G
AU - Bayhan GI
AU - Keles S
AU - Kiykim A
AU - Hancerli S
AU - Haerynck F
AU - Florkin B
AU - Hatipoglu N
AU - Ozcelik T
AU - Morelle G
AU - Zatz M
AU - Ng LFP
AU - Lye DC
AU - Young BE
AU - Leo YS
AU - Dalgard CL
AU - Lifton RP
AU - Renia L
AU - Meyts I
AU - Jouanguy E
AU - Hammarstrom L
AU - Panhammarstrom Q
AU - Boisson B
AU - Bastard P
AU - Su HC
AU - Boissondupuis S
AU - Abel L
AU - Rice CM
AU - Zhang SY
AU - Cobat A
AU - Casanova JL
TI - Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia
JO - Journal of Experimental Medicine
VL - 219
IS - 8
SP -
EP -
PY - 2022
ER -

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