Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia

Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia Publisher

Zhang Q^{1, 2, 3} ; Matuozzo D^{2, 3} ; Le Pen J⁴ ; Lee D^{1, 2, 3} ; Moens L⁴ ; Asano T¹ ; Bohlen J^{2, 3} ; Liu Z¹ ; Moncadavelez M¹ ; Kendirdemirkol Y¹ ; Jing H⁶ ; Bizien L^{2, 3} ; Marchal A^{2, 3} ; Abolhassani H^{7, 8} Show All Authors

Zhang Q^{1, 2, 3}
Matuozzo D^{2, 3}
Le Pen J⁴
Lee D^{1, 2, 3}
Moens L⁴
Asano T¹
Bohlen J^{2, 3}
Liu Z¹
Moncadavelez M¹
Kendirdemirkol Y¹
Jing H⁶
Bizien L^{2, 3}
Marchal A^{2, 3}
Abolhassani H^{7, 8}
Delafontaine S^{5, 9}
Bucciol G⁵
Bayhan GI¹⁰
Keles S¹¹
Kiykim A¹²
Hancerli S¹³
Haerynck F¹⁴
Florkin B¹⁵
Hatipoglu N¹⁶
Ozcelik T¹⁷
Morelle G¹⁸
Zatz M¹⁹
Ng LFP²⁰
Lye DC^{21, 22, 23, 24}
Young BE^{21, 23, 24}
Leo YS^{21, 22, 23, 24}
Dalgard CL^{25, 26}
Lifton RP^{27, 28, 29}
Renia L^{20, 23, 30}
Meyts I⁵
Jouanguy E^{1, 2, 3}
Hammarstrom L⁷
Panhammarstrom Q⁷
Boisson B^{1, 2, 3}
Bastard P^{1, 2, 3, 31}
Su HC⁶
Boissondupuis S^{1, 2, 3}
Abel L^{1, 2, 3}
Rice CM⁴
Zhang SY^{1, 2, 3}
Cobat A^{1, 2, 3}
Casanova JL^{1, 2, 3, 31, 32}

Show Affiliations

1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, United States
2. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France
3. University Paris Cite, Imagine Institute, Paris, France
4. Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, NY, United States
5. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
6. Laboratory of Clinical Immunology and Microbiology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
7. Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
8. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
10. Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey
11. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey
12. Istanbul University-Cerrahpasa, Pediatric Allergy and Immunology, Istanbul, Turkey
13. Department of Pediatrics (Infectious Diseases), Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
14. Department of Pediatric Immunology and Pulmonology, Department of Internal Medicine and Pediatrics, Centre for Primary Immunodeficiency Ghent, PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
15. Department of Pediatrics, Hopital de la Citadelle, Liege, Belgium
16. Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
17. Department of Molecular Biology and Genetics, Bilkent University, Bilkent-Ankara, Turkey
18. Department of General Pediatrics, Bicetre Hospital, Assistance Publique â€“ Hopitaux de Paris, University of Paris Saclay, Le Kremlin-Bicetre, France
19. Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil
20. A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
21. National Centre for Infectious Diseases, Singapore, Singapore
22. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
23. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
24. Tan Tock Seng Hospital, Singapore, Singapore
25. The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
26. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
27. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, United States
28. Department of Genetics, Yale University School of Medicine, New Haven, CT, United States
29. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, United States
30. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
31. Department of Pediatrics, Necker Hospital for Sick Children, Paris, France
32. Howard Hughes Medical Institute, New York, NY, United States

Source: Journal of Experimental Medicine Published:2022

Abstract

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (<16 yr old) hospitalized for COVID-19 pneumonia, we report 12 children (10.7%) aged 1.5–13 yr with critical (7 children), severe (3), and moderate (2) pneumonia and 4 of the 15 known clinically recessive and biochemically complete inborn errors of type I IFN immunity: X-linked recessive TLR7 deficiency (7 children) and autosomal recessive IFNAR1 (1), STAT2 (1), or TYK2 (3) deficiencies. Fibroblasts deficient for IFNAR1, STAT2, or TYK2 are highly vulnerable to SARS-CoV-2. These 15 deficiencies were not found in 1,224 children and adults with benign SARS-CoV-2 infection without pneumonia (P = 1.2 × 10−11) and with overlapping age, sex, consanguinity, and ethnicity characteristics. Recessive complete deficiencies of type I IFN immunity may underlie ∼10% of hospitalizations for COVID-19 pneumonia in children. © 2022 Zhang et al.

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Style	Citing Format
MLA	Zhang Q, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine, vol. 219, no. 8, 2022, pp. -.
APA	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncadavelez M, Kendirdemirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, Bayhan GI, Keles S, Kiykim A, ... Casanova JL (2022). Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine, 219(8), -.
Chicago	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine 219, no. 8 (2022): -.
Harvard	Zhang Q et al. (2022) 'Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia', Journal of Experimental Medicine, 219(8), pp. -.
Vancouver	Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, et al.. Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine. 2022;219(8):-.
BibTex	@article{ author = {Zhang Q and Matuozzo D and Le Pen J and Lee D and Moens L and Asano T and Bohlen J and Liu Z and Moncadavelez M and Kendirdemirkol Y and Jing H and Bizien L and Marchal A and Abolhassani H and Delafontaine S and Bucciol G and Bayhan GI and Keles S and Kiykim A and Hancerli S and Haerynck F and Florkin B and Hatipoglu N and Ozcelik T and Morelle G and Zatz M and Ng LFP and Lye DC and Young BE and Leo YS and Dalgard CL and Lifton RP and Renia L and Meyts I and Jouanguy E and Hammarstrom L and Panhammarstrom Q and Boisson B and Bastard P and Su HC and Boissondupuis S and Abel L and Rice CM and Zhang SY and Cobat A and Casanova JL}, title = {Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia}, journal = {Journal of Experimental Medicine}, volume = {219}, number = {8}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zhang Q AU - Matuozzo D AU - Le Pen J AU - Lee D AU - Moens L AU - Asano T AU - Bohlen J AU - Liu Z AU - Moncadavelez M AU - Kendirdemirkol Y AU - Jing H AU - Bizien L AU - Marchal A AU - Abolhassani H AU - Delafontaine S AU - Bucciol G AU - Bayhan GI AU - Keles S AU - Kiykim A AU - Hancerli S AU - Haerynck F AU - Florkin B AU - Hatipoglu N AU - Ozcelik T AU - Morelle G AU - Zatz M AU - Ng LFP AU - Lye DC AU - Young BE AU - Leo YS AU - Dalgard CL AU - Lifton RP AU - Renia L AU - Meyts I AU - Jouanguy E AU - Hammarstrom L AU - Panhammarstrom Q AU - Boisson B AU - Bastard P AU - Su HC AU - Boissondupuis S AU - Abel L AU - Rice CM AU - Zhang SY AU - Cobat A AU - Casanova JL TI - Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia JO - Journal of Experimental Medicine VL - 219 IS - 8 SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Zhang Q, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine, vol. 219, no. 8, 2022, pp. -.

APA

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncadavelez M, Kendirdemirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, Bayhan GI, Keles S, Kiykim A, ... Casanova JL (2022). Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine, 219(8), -.

Chicago

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, et al.. "Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia." Journal of Experimental Medicine 219, no. 8 (2022): -.

Harvard

Zhang Q et al. (2022) 'Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia', Journal of Experimental Medicine, 219(8), pp. -.

Vancouver

Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, et al.. Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia. Journal of Experimental Medicine. 2022;219(8):-.

BibTex

@article{ author = {Zhang Q and Matuozzo D and Le Pen J and Lee D and Moens L and Asano T and Bohlen J and Liu Z and Moncadavelez M and Kendirdemirkol Y and Jing H and Bizien L and Marchal A and Abolhassani H and Delafontaine S and Bucciol G and Bayhan GI and Keles S and Kiykim A and Hancerli S and Haerynck F and Florkin B and Hatipoglu N and Ozcelik T and Morelle G and Zatz M and Ng LFP and Lye DC and Young BE and Leo YS and Dalgard CL and Lifton RP and Renia L and Meyts I and Jouanguy E and Hammarstrom L and Panhammarstrom Q and Boisson B and Bastard P and Su HC and Boissondupuis S and Abel L and Rice CM and Zhang SY and Cobat A and Casanova JL}, title = {Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia}, journal = {Journal of Experimental Medicine}, volume = {219}, number = {8}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Zhang Q
AU - Matuozzo D
AU - Le Pen J
AU - Lee D
AU - Moens L
AU - Asano T
AU - Bohlen J
AU - Liu Z
AU - Moncadavelez M
AU - Kendirdemirkol Y
AU - Jing H
AU - Bizien L
AU - Marchal A
AU - Abolhassani H
AU - Delafontaine S
AU - Bucciol G
AU - Bayhan GI
AU - Keles S
AU - Kiykim A
AU - Hancerli S
AU - Haerynck F
AU - Florkin B
AU - Hatipoglu N
AU - Ozcelik T
AU - Morelle G
AU - Zatz M
AU - Ng LFP
AU - Lye DC
AU - Young BE
AU - Leo YS
AU - Dalgard CL
AU - Lifton RP
AU - Renia L
AU - Meyts I
AU - Jouanguy E
AU - Hammarstrom L
AU - Panhammarstrom Q
AU - Boisson B
AU - Bastard P
AU - Su HC
AU - Boissondupuis S
AU - Abel L
AU - Rice CM
AU - Zhang SY
AU - Cobat A
AU - Casanova JL
TI - Recessive Inborn Errors of Type I Ifn Immunity in Children With Covid-19 Pneumonia
JO - Journal of Experimental Medicine
VL - 219
IS - 8
SP -
EP -
PY - 2022
ER -

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