Evaluation of the Correlation Between Cd44, Tumor Prognosis and the 5-Year Survival Rate in Patients With Oral Tongue Scc



Kaboodkhani R¹ ; Karimi E² ; Ashtiani MTK² ; Kowkabi S³ ; Firouzifar MR⁴ ; Yazdani F⁵ ; Yazdani N² Show Affiliations
Source: Iranian Journal of Otorhinolaryngology Published:2016

Abstract

Introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis. Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody. Results: There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival. Conclusion: There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors. © 2016 Mashhad University of Medical Sciences. All rights reserved.