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Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma Publisher Pubmed



Zanjani LS1 ; Madjd Z1, 2 ; Abolhasani M1, 3 ; Rasti A1 ; Fodstad O4, 5 ; Andersson Y4 ; Asgari M1, 3
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Authors Affiliations
  1. 1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, 0424, Norway
  5. 5. Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 0310, Norway

Source: Biomarkers in Medicine Published:2018


Abstract

Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. Discussion & conclusion: Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC. © 2018 Future Medicine Ltd.
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