Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study

Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study Publisher Pubmed

Mohamadzadeh O^{1, 2} ; Sadrehosseini SM³ ; Tabari A³ ; Ghanaati H⁴ ; Zeinalizadeh M^{1, 2}

Show Affiliations

1. Brain and Spinal Injury Research Center (BASIR), Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Otolaryngology-Head and Neck Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran

Source: World Neurosurgery Published:2023

Abstract

Objective: Visual impairment has been reported as the most common clinical manifestation of pituitary adenoma (PA) due to the compressive effect of the tumor. This prospective study aimed to evaluate the predictive role of diffusion tensor imaging (DTI) in the visual improvement of patients with PA, who were candidates for endoscopic endonasal surgery. Methods: A total of 13 patients (male, 8; female, 5) with visual impairment due to pituitary macroadenoma were enrolled in this study. The DTI findings and visual parameters, including visual acuity (VA), visual field (VF), and visual evoked potential (VEP), were recorded for all participants before and 3 months after surgery. Results: Significant recovery was reported in both VA and VF following PA surgery (P < 0.001). The results of perimetry indicated recovery in all quadrants, except for the lower nasal quadrant of the right eye. The tumor volume showed no significant association with the preoperative optic nerve, optic tract, and chiasm fractional anisotropy (FA) or mean diffusivity (MD). The VA and VF recoveries were more likely in patients with a lower preoperative optic nerve MD. Besides, increased preoperative FA of the optic nerve was associated with a higher probability of VA recovery. No significant correlation was found between the optic tract MD and FA values and visual improvement. Overall, MD values below 0.0021 and FA values above 0.1689 could predict a good prognosis of VA recovery after surgery. Conclusions: DTI may have a predictive value in estimating visual improvement in patients with PA preoperatively. © 2023

Style	Citing Format
MLA	Mohamadzadeh O, et al.. "Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study." World Neurosurgery, vol. 172, no. , 2023, pp. e326-e334.
APA	Mohamadzadeh O, Sadrehosseini SM, Tabari A, Ghanaati H, Zeinalizadeh M (2023). Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study. World Neurosurgery, 172(), e326-e334.
Chicago	Mohamadzadeh O, Sadrehosseini SM, Tabari A, Ghanaati H, Zeinalizadeh M. "Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study." World Neurosurgery 172, no. (2023): e326-e334.
Harvard	Mohamadzadeh O et al. (2023) 'Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study', World Neurosurgery, 172(), pp. e326-e334.
Vancouver	Mohamadzadeh O, Sadrehosseini SM, Tabari A, Ghanaati H, Zeinalizadeh M. Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study. World Neurosurgery. 2023;172():e326-e334.
BibTex	@article{ author = {Mohamadzadeh O and Sadrehosseini SM and Tabari A and Ghanaati H and Zeinalizadeh M}, title = {Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study}, journal = {World Neurosurgery}, volume = {172}, number = {}, pages = {e326-e334}, year = {2023} }
RIS	TY - JOUR AU - Mohamadzadeh O AU - Sadrehosseini SM AU - Tabari A AU - Ghanaati H AU - Zeinalizadeh M TI - Can Preoperative Diffusion Tensor Imaging Tractography Predict the Visual Outcomes of Patients With Pituitary Macroadenomas? a Prospective Pilot Study JO - World Neurosurgery VL - 172 IS - SP - e326 EP - e334 PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract