Parenteral Systems for Statin Delivery: A Review Publisher Pubmed



Korani S¹ ; Bahrami S² ; Korani M³ ; Banach M^{4, 5} ; Johnston TP⁶ ; Sahebkar A^{7, 8, 9, 10} Show Affiliations
Source: Lipids in Health and Disease Published:2019

Abstract

The oral route of drug administration is the most common and convenient route for dosing statin drugs, and, in fact, most medications, because of ease of drug delivery, patient compliance, and cost-effectiveness. However, the oral administration of statin drugs has disadvantages such as hepatic first-pass metabolism and degradation within the gastrointestinal tract that limit their overall bioavailability. This review introduces several diverse non-oral delivery methods for the administration of statins. These alternative delivery systems and routes of administration are varied and are capable of improving the bioavailability and therapeutic efficacy of statin drugs. © 2019 The Author(s).