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Effects of Statins on the Biological Features of Mesenchymal Stem Cells and Therapeutic Implications Publisher Pubmed



Gorabi AM1 ; Kiaie N1 ; Pirro M2 ; Bianconi V2 ; Jamialahmadi T3, 4 ; Sahebkar A5, 6, 7
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
  3. 3. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Halal Research Center of IRI, FDA, Tehran, Iran
  6. 6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Heart Failure Reviews Published:2021


Abstract

Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought about some beneficial effects on improving the therapeutic outcomes of cell therapy and tissue engineering approaches. In this review, the impact of statins on mesenchymal stem cell behaviors including differentiation, apoptosis, proliferation, migration, and angiogenesis, as well as molecular pathways which are responsible for such phenomena, are discussed. A better understanding of pathways and mechanisms of statin-mediated effects on mesenchymal stem cells will pave the way for the expansion of statin applications. Furthermore, since designing a suitable carrier for statins is required to maintain a sufficient dose of active statins at the desired site of the body, different systems for local delivery of statins are also reviewed. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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