Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors

Ziarani GM^{1, 2} ; Asadi S¹ ; Badiei A³ ; Sharifi A⁴ ; Amanlou M⁴

Show Affiliations

1. Department of Chemistry, Alzahra University, Vanak Square, Tehran, Iran
2. National Laboratory of Pharmaceutical Research, Alzahra University, Tehran, Iran
3. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
4. Drug Design and Development Research Centre, Department of Medicinal Chemistry, TehranUniversity of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pharmaceutical Research Published:2016

Abstract

New series of spiro indeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst. The inhibitory activities of synthesized compounds were tested against Jack bean urease using Berthelot colorimetric assay and docking simulation using AutoDock 4.2. The compound 4a with IC50 =1.94 μM has the most inhibitor activity in this study. Other derivatives such as 4b, 4d, 4e and 7a were found to be more potent urease inhibitors than the standard inhibitor hydroxyurea, yielding IC50 values of 4.35, 5.557, 7.44, 2.81 and 14.46 μM, respectively (IC50 of hydroxyurea = 100 μM). © 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Related Docs

View other Related Docs

1. Green Synthesis and Urease Inhibitory Activity of Spiro-Pyrimidinethiones/Spiro-Pyrimidinones-Barbituric Acid Derivatives, Iranian Journal of Pharmaceutical Research (2015)

2. Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4-Triazole Derivatives As Novel Potent Urease Inhibitors: Proposing Repositioning Candidate, Chemistry and Biodiversity (2020)

3. Urease Inhibitory Activities of Some Commonly Consumed Herbal Medicines, Iranian Journal of Pharmaceutical Research (2015)

4. Screening and Identification of Herbal Urease Inhibitors Using Surface Plasmon Resonance Biosensor, Research Journal of Pharmacognosy (2021)

5. Prediction of Dual Agents As an Activator of Mutant P53 and Inhibitor of Hsp90 by Docking, Molecular Dynamic Simulation and Virtual Screening, Journal of Molecular Graphics and Modelling (2015)

6. Erp57 Protein Activators for Management of Fertility by Virtual Screening and Molecular Dynamic Studies, Biointerface Research in Applied Chemistry (2023)

7. Design, Synthesis, Docking Study and Urease Inhibitory Activity Evaluation of Novel 2-((5-Amino-1,3,4-Thiadiazol-2-Yl)Thio)-N-Arylacetamide Derivatives, Medicinal Chemistry Research (2021)

8. Structure-Based Virtual Screening for Defeating Drug Resistant Form of Egfr Protein, Combinatorial Chemistry and High Throughput Screening (2016)

Experts (# of related papers)

View all Related Experts

Massoud Amanlou (21)

Mahmood Biglar (4)

Other Related Docs

9. Discovery of Novel Dual Inhibitors Against Mdm2 and Mdmx Proteins by in Silico Approaches and Binding Assay, Life Sciences (2016)

10. Analysis of B-Rafv600einhibitors Using 2D and 3D-Qsar, Molecular Docking and Pharmacophore Studies, Molecular Diversity (2015)

11. 3D-Qsar, Molecular Docking, and Molecular Dynamic Simulations for Prediction of New Hsp90 Inhibitors Based on Isoxazole Scaffold, Journal of Biomolecular Structure and Dynamics (2018)

12. Potent Human Telomerase Inhibitors: Molecular Dynamic Simulations, Multiple Pharmacophore-Based Virtual Screening, and Biochemical Assays, Journal of Chemical Information and Modeling (2015)

13. Synthesis, Molecular Docking, and Biological Evaluation of Nitroimidazole Derivatives As Potent Urease Inhibitors, Medicinal Chemistry Research (2021)

14. Combined Virtual Screening, Dft Calculations and Molecular Dynamics Simulations to Discovery of Potent Mmp-9 Inhibitors, Letters in Drug Design and Discovery (2019)

15. Tetracyclines As a Potential Antiviral Therapy Against Crimean Congo Hemorrhagic Fever Virus: Docking and Molecular Dynamic Studies, Computational Biology and Chemistry (2017)

16. Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives As Anti-Gram-Positive and Anti-H. Pylori Agents, Mini-Reviews in Medicinal Chemistry (2019)

17. New Heat Shock Protein (Hsp90) Inhibitors, Designed by Pharmacophore Modeling and Virtual Screening: Synthesis, Biological Evaluation and Molecular Dynamics Studies, Journal of Biomolecular Structure and Dynamics (2020)

18. 3D-Qsar and Docking Studies on Adenosine A2a Receptor Antagonists by the Comfa Method, SAR and QSAR in Environmental Research (2015)

19. Isoindolin-1-Ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation, ACS Omega (2022)

20. Prediction of New Hsp90 Inhibitors Based on 3,4-Isoxazolediamide Scaffold Using Qsar Study, Molecular Docking and Molecular Dynamic Simulation, DARU# Journal of Pharmaceutical Sciences (2017)

21. Facile One-Pot Four-Component Synthesis of 3,4-Dihydro-2-Pyridone Derivatives: Novel Urease Inhibitor Scaffold, Research in Pharmaceutical Sciences (2017)

22. A New Insight Into Mushroom Tyrosinase Inhibitors: Docking, Pharmacophore-Based Virtual Screening, and Molecular Modeling Studies, Journal of Biomolecular Structure and Dynamics (2015)

23. Inhibition of Liver Alanine Aminotransferase and Aspartate Aminotransferase by Hesperidin and Its Aglycone Hesperetin: An in Vitro and in Silico Study, Life Sciences (2017)

24. A Study on Quantitative Structure-Activity Relationship and Molecular Docking of Metalloproteinase Inhibitors Based on L-Tyrosine Scaffold, DARU# Journal of Pharmaceutical Sciences (2015)

Style	Citing Format
MLA	Ziarani GM, et al.. "Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors." Iranian Journal of Pharmaceutical Research, vol. 15, no. , 2016, pp. 55-63.
APA	Ziarani GM, Asadi S, Badiei A, Sharifi A, Amanlou M (2016). Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors. Iranian Journal of Pharmaceutical Research, 15(), 55-63.
Chicago	Ziarani GM, Asadi S, Badiei A, Sharifi A, Amanlou M. "Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors." Iranian Journal of Pharmaceutical Research 15, no. (2016): 55-63.
Harvard	Ziarani GM et al. (2016) 'Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors', Iranian Journal of Pharmaceutical Research, 15(), pp. 55-63.
Vancouver	Ziarani GM, Asadi S, Badiei A, Sharifi A, Amanlou M. Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors. Iranian Journal of Pharmaceutical Research. 2016;15():55-63.
BibTex	@article{ author = {Ziarani GM and Asadi S and Badiei A and Sharifi A and Amanlou M}, title = {Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors}, journal = {Iranian Journal of Pharmaceutical Research}, volume = {15}, number = {}, pages = {55-63}, year = {2016} }
RIS	TY - JOUR AU - Ziarani GM AU - Asadi S AU - Badiei A AU - Sharifi A AU - Amanlou M TI - Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors JO - Iranian Journal of Pharmaceutical Research VL - 15 IS - SP - 55 EP - 63 PY - 2016 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract