Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents

Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents Publisher Pubmed

Moghimi S¹ ; Goligarmroodi F² ; Allahyaridevin M³ ; Pilali H² ; Hassanzadeh M¹ ; Mahernia S¹ ; Mahdavi M⁴ ; Firoozpour L² ; Amanlou M^{1, 5} ; Foroumadi A^{1, 5}

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1. The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, School of Pharmacy, Urmia University of Medical Science, Urmia, Iran
4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Archiv der Pharmazie Published:2018

Abstract

Considering the importance of urease inhibitors in the treatment of ureolytic bacterial infections, in this work, the synthesis of novel, aryl urea-triazole-based derivatives as effective urease inhibitors is described. Dichloro-substituted derivative 4o, with IC50 = 22.81 ± 0.05 μM, is found to be the most potent urease inhibitor, determined by Berthelot colorimetric assay. Docking studies were also carried out for compound 4o to confirm the effective interactions with the urease active site. © 2018 Deutsche Pharmazeutische Gesellschaft

Style	Citing Format
MLA	Moghimi S, et al.. "Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents." Archiv der Pharmazie, vol. 351, no. 7, 2018, pp. -.
APA	Moghimi S, Goligarmroodi F, Allahyaridevin M, Pilali H, Hassanzadeh M, Mahernia S, Mahdavi M, Firoozpour L, Amanlou M, Foroumadi A (2018). Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents. Archiv der Pharmazie, 351(7), -.
Chicago	Moghimi S, Goligarmroodi F, Allahyaridevin M, Pilali H, Hassanzadeh M, Mahernia S, Mahdavi M, Firoozpour L, Amanlou M, Foroumadi A. "Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents." Archiv der Pharmazie 351, no. 7 (2018): -.
Harvard	Moghimi S et al. (2018) 'Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents', Archiv der Pharmazie, 351(7), pp. -.
Vancouver	Moghimi S, Goligarmroodi F, Allahyaridevin M, Pilali H, Hassanzadeh M, Mahernia S, et al.. Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents. Archiv der Pharmazie. 2018;351(7):-.
BibTex	@article{ author = {Moghimi S and Goligarmroodi F and Allahyaridevin M and Pilali H and Hassanzadeh M and Mahernia S and Mahdavi M and Firoozpour L and Amanlou M and Foroumadi A}, title = {Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents}, journal = {Archiv der Pharmazie}, volume = {351}, number = {7}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Moghimi S AU - Goligarmroodi F AU - Allahyaridevin M AU - Pilali H AU - Hassanzadeh M AU - Mahernia S AU - Mahdavi M AU - Firoozpour L AU - Amanlou M AU - Foroumadi A TI - Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents JO - Archiv der Pharmazie VL - 351 IS - 7 SP - EP - PY - 2018 ER -

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Abstract