Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease

Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease Publisher Pubmed

Parvaneh N^{1, 3, 5, 7, 9, 11, 13, 15} ; Pourakbari B^{1, 3, 5, 7, 9, 11, 13, 15} ; Rezaei N^{1, 3, 5, 7, 9, 11, 13, 15} ; Omidvar A^{1, 3, 5, 7, 9, 11, 13, 15} ; Sabouni F^{1, 3, 5, 7, 9, 11, 13, 15} ; Mahmoudi S^{1, 3, 5, 7, 9, 11, 13, 15} ; Khotaei G^{1, 3, 5, 7, 9, 11, 13, 15} ; Mamishi S^{1, 3, 5, 7, 9, 11, 13, 15}

Show Affiliations

1. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
2. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
3. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
4. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
5. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
6. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
7. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
8. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
9. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
10. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
11. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
12. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
13. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
14. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran
15. Department of Infectious Disease, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Iran
16. Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran

Source: Allergologia et immunopathologia Published:2015

Abstract

INTRODUCTION: Diagnosis of specific molecular defects of Mendelian susceptibility to mycobacterial diseases (MSMD) patients is important with respect to their clinical outcomes and their response to therapy. The aim of this study was to perform functional tests on blood samples of a group of patients who were suspected of having MSMD.; METHODS: This study was performed on 11 cases who had mycobacterial infections and suspected MSMD. Whole blood cell culture was performed in presence of different stimulators. The supernatants were assayed for IFN-γ, IL-12p40 by ELISA method.; RESULTS: All patients presented with complications of BCG vaccine in the form of localised lymphadenitis or disseminated BCG infection and chronic mycobacterial osteomyelitis. Infections with Salmonella species occurred in two patients. In-vitro studies showed that 10 cases had impaired response to IL-12. However, the baseline levels of IL-12p40 were normal, while one of our patients may have a potential IFN-γ signalling defect or an IL-12p40 defect.; CONCLUSIONS: Early detection of MSMD and commencing of appropriate combination therapy could prevent severe or even fatal complications of uncontrolled mycobacterial infections. Copyright © 2014 SEICAP. Published by Elsevier Espana. All rights reserved.

Style	Citing Format
MLA	Parvaneh N, et al.. "Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease." Allergologia et immunopathologia, vol. 43, no. 5, 2015, pp. 456-460.
APA	Parvaneh N, Pourakbari B, Rezaei N, Omidvar A, Sabouni F, Mahmoudi S, Khotaei G, Mamishi S (2015). Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease. Allergologia et immunopathologia, 43(5), 456-460.
Chicago	Parvaneh N, Pourakbari B, Rezaei N, Omidvar A, Sabouni F, Mahmoudi S, Khotaei G, Mamishi S. "Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease." Allergologia et immunopathologia 43, no. 5 (2015): 456-460.
Harvard	Parvaneh N et al. (2015) 'Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease', Allergologia et immunopathologia, 43(5), pp. 456-460.
Vancouver	Parvaneh N, Pourakbari B, Rezaei N, Omidvar A, Sabouni F, Mahmoudi S, et al.. Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease. Allergologia et immunopathologia. 2015;43(5):456-460.
BibTex	@article{ author = {Parvaneh N and Pourakbari B and Rezaei N and Omidvar A and Sabouni F and Mahmoudi S and Khotaei G and Mamishi S}, title = {Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease}, journal = {Allergologia et immunopathologia}, volume = {43}, number = {5}, pages = {456-460}, year = {2015} }
RIS	TY - JOUR AU - Parvaneh N AU - Pourakbari B AU - Rezaei N AU - Omidvar A AU - Sabouni F AU - Mahmoudi S AU - Khotaei G AU - Mamishi S TI - Impaired In-Vitro Responses to Il-12 and Ifn-Γ in Iranian Patients With Mendelian Susceptibility to Mycobacterial Disease JO - Allergologia et immunopathologia VL - 43 IS - 5 SP - 456 EP - 460 PY - 2015 ER -

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