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The Effects of Probiotic Supplementation on Glycemic Control, Insulin Resistance and Inflammatory Biomarkers of Type 2 Diabetic Patients



Ahmadian F1 ; Ejtahed HS2 ; Javadi M3 ; Razmpoosh E4 ; Mirmiran P5 ; Azizi F6
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Children Growth Research Center, Qazvin University of Medical Sciences, Tehran, Iran
  4. 4. Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Science, Tehran, Iran
  5. 5. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Endocrinology and Metabolism Published:2017

Abstract

Introduction: Systemic inflammation plays a main role in the incidence of diabetes complications. Probiotics can be used in the treatment of diabetes complications for its anti- inflammatory properties. This study aimed to investigate the effects of probiotic supplement on glycemia, insulin resistance and inflammatory markers in patients with type 2 diabetes. Materials and Methods: This randomized double blind clinical trial was carried out on 59 diabetic patients, aged 25-65 years, referred to the Taleghani Hospital in Tehran. They were randomly divided in 2 groups, the probiotic and the placebo. Patients in each group received 2 capsules per day for 6 weeks. Fasting blood samples were taken at baseline and after intervention to evaluate glycemic control, insulin resistance and inflammatory biomarkers. Results: Mean fasting blood glucose was significantly decreased by 9% (132.7±34 vs. 146.5±44) in the probiotic group during the intervention (P=0.001). Results of the analysis of covariance showed that there were statistically significant differences between the two groups in fasting blood glucose and insulin resistance, whereas there were none observed in IL-6 and TNF between the two groups after intervention. Conclusions: The results of the present study indicate that probiotic consumption may help in diabetes control through reducing glycemia and insulin resistance. © 2017, Endocrine Research Center. All rights reserved.
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