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Treatment of Resistant Visceral Leishmaniasis With Interferon Gamma in Combination With Liposomal Amphotericin B and Allopurinol Publisher Pubmed



Khodabandeh M1 ; Rostami A2 ; Borhani K1 ; Gamble HR3 ; Mohammadi M4
Authors
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Authors Affiliations
  1. 1. Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  3. 3. National Academy of Sciences, Washington, DC, United States
  4. 4. Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: Parasitology International Published:2019


Abstract

This report describes the first case of visceral leishmaniasis (VL)resistant to pentavalent antimonials and also the first use of combinational therapy in Iran. The patient was a two-year old boy, from a non-endemic area for leishmaniasis in northern Iran, presenting with pentavalent antimonial resistant VL. Additional treatment with conventional and liposomal amphotericin B was not effective. A complete cure was achieved following a three week treatment with liposomal amphotericin B (5 mg/kg/day for 5 days, then on the 14th and 21st days), allopurinol (25 mg/day for 5 days, then on the 14th and 21st days)and interferon gamma (50 μg/m2 subcutaneously three times weekly). Our results suggest a need for further studies to identify resistant Leishmania species and their susceptibility to different treatment regimens. © 2019 Elsevier B.V.
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