Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior

Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior Publisher Pubmed

Esmaeili M¹ ; Aghajani M¹ ; Abbasalipourkabir R² ; Amani A^{1, 3}

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1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biochemistry, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
3. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2016

Abstract

Advantages of lipid nanoparticles for pulmonary applications are possibility of deep lung deposition with prolonged release and low toxicity. This study aimed to evaluate the effects of formulation and processing parameters on particle size of prepared SLNs. Budesonide-loaded solid lipid nanoparticles (BUD-SLNs) were prepared with different values of drug content, ultrasonication amplitude, and homogenization time and the data were modeled using artificial neural networks (ANNs). Optimal conditions for fabrication of small-sized particles of 170–200 nm were found to be low drug content with high-amplitude and high-homogenization time. In vitro aerosolization performance of BUD-SLNs was then compared to that of commercial budesonide which indicated enhancement in fine particle fraction value. © 2016 Taylor & Francis.

2. Aerosol Delivery of Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Treatment Approach Against the Respiratory Disorders, Physiology and Pharmacology (Iran) (2017)

3. Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion, Iranian Journal of Pharmaceutical Research (2016)

4. Toxicity Concerns of Nanocarriers, Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes (2017)

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Seyed Mahdi Rezayat Sorkhabadi (1)

Fatemeh Atyabi (1)

Style	Citing Format
MLA	Esmaeili M, et al.. "Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior." Artificial Cells# Nanomedicine and Biotechnology, vol. 44, no. 8, 2016, pp. 1964-1971.
APA	Esmaeili M, Aghajani M, Abbasalipourkabir R, Amani A (2016). Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior. Artificial Cells# Nanomedicine and Biotechnology, 44(8), 1964-1971.
Chicago	Esmaeili M, Aghajani M, Abbasalipourkabir R, Amani A. "Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior." Artificial Cells# Nanomedicine and Biotechnology 44, no. 8 (2016): 1964-1971.
Harvard	Esmaeili M et al. (2016) 'Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior', Artificial Cells# Nanomedicine and Biotechnology, 44(8), pp. 1964-1971.
Vancouver	Esmaeili M, Aghajani M, Abbasalipourkabir R, Amani A. Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior. Artificial Cells# Nanomedicine and Biotechnology. 2016;44(8):1964-1971.
BibTex	@article{ author = {Esmaeili M and Aghajani M and Abbasalipourkabir R and Amani A}, title = {Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {44}, number = {8}, pages = {1964-1971}, year = {2016} }
RIS	TY - JOUR AU - Esmaeili M AU - Aghajani M AU - Abbasalipourkabir R AU - Amani A TI - Budesonide-Loaded Solid Lipid Nanoparticles for Pulmonary Delivery: Preparation, Optimization, and Aerodynamic Behavior JO - Artificial Cells# Nanomedicine and Biotechnology VL - 44 IS - 8 SP - 1964 EP - 1971 PY - 2016 ER -

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